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1xdx

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(New page: 200px<br /><applet load="1xdx" size="450" color="white" frame="true" align="right" spinBox="true" caption="1xdx" /> '''Solution Structure of the Tctex1 Light Chain...)
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[[Image:1xdx.gif|left|200px]]<br /><applet load="1xdx" size="450" color="white" frame="true" align="right" spinBox="true"
 
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'''Solution Structure of the Tctex1 Light Chain From Chlamydomonas Inner Dynein Arm I1'''<br />
 
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==Overview==
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==Solution Structure of the Tctex1 Light Chain From Chlamydomonas Inner Dynein Arm I1==
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Tctex1 is a light chain found in both cytoplasmic and flagellar dyneins, and is involved in many fundamental cellular activities, including, rhodopsin transport within photoreceptors, and may function in the, non-Mendelian transmission of t haplotypes in mice. Here, we present the, NMR solution structure for the Tctex1 dimer from Chlamydomonas axonemal, inner dynein arm I1. Structural comparisons reveal a strong similarity, with the LC8 dynein light chain dimer, including formation of a, strand-switched beta sheet interface. Analysis of the Tctex1 structure, enables the dynein intermediate chain binding site to be identified and, suggests a mechanism by which cargo proteins might be attached to this, microtubule motor complex. Comparison with the alternate dynein light, chain rp3 reveals how the specificity of dynein-cargo interactions, mediated by these dynein components is achieved. In addition, this, structure provides insight into the consequences of the mutations found in, the t haplotype forms of this protein.
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<StructureSection load='1xdx' size='340' side='right'caption='[[1xdx]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1xdx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Chlamydomonas_reinhardtii Chlamydomonas reinhardtii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XDX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XDX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xdx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xdx OCA], [https://pdbe.org/1xdx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xdx RCSB], [https://www.ebi.ac.uk/pdbsum/1xdx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xdx ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/O64980_CHLRE O64980_CHLRE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xd/1xdx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xdx ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Tctex1 is a light chain found in both cytoplasmic and flagellar dyneins and is involved in many fundamental cellular activities, including rhodopsin transport within photoreceptors, and may function in the non-Mendelian transmission of t haplotypes in mice. Here, we present the NMR solution structure for the Tctex1 dimer from Chlamydomonas axonemal inner dynein arm I1. Structural comparisons reveal a strong similarity with the LC8 dynein light chain dimer, including formation of a strand-switched beta sheet interface. Analysis of the Tctex1 structure enables the dynein intermediate chain binding site to be identified and suggests a mechanism by which cargo proteins might be attached to this microtubule motor complex. Comparison with the alternate dynein light chain rp3 reveals how the specificity of dynein-cargo interactions mediated by these dynein components is achieved. In addition, this structure provides insight into the consequences of the mutations found in the t haplotype forms of this protein.
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==About this Structure==
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Solution structure of the Tctex1 dimer reveals a mechanism for dynein-cargo interactions.,Wu H, Maciejewski MW, Takebe S, King SM Structure. 2005 Feb;13(2):213-23. PMID:15698565<ref>PMID:15698565</ref>
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1XDX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Chlamydomonas_reinhardtii Chlamydomonas reinhardtii]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1XDX OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Solution structure of the Tctex1 dimer reveals a mechanism for dynein-cargo interactions., Wu H, Maciejewski MW, Takebe S, King SM, Structure. 2005 Feb;13(2):213-23. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15698565 15698565]
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</div>
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[[Category: Chlamydomonas reinhardtii]]
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<div class="pdbe-citations 1xdx" style="background-color:#fffaf0;"></div>
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[[Category: Single protein]]
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[[Category: King, S.M.]]
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[[Category: Maciejewski, M.W.]]
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[[Category: Takebe, S.]]
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[[Category: Wu, H.]]
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[[Category: chlamydomonas flagella]]
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[[Category: nmr solution structure]]
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[[Category: tctex1 dimer]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 01:57:37 2007''
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==See Also==
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*[[Dynein 3D structures|Dynein 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Chlamydomonas reinhardtii]]
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[[Category: Large Structures]]
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[[Category: King SM]]
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[[Category: Maciejewski MW]]
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[[Category: Takebe S]]
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[[Category: Wu H]]

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Solution Structure of the Tctex1 Light Chain From Chlamydomonas Inner Dynein Arm I1

PDB ID 1xdx

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