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2wie

From Proteopedia

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{{Seed}}
 
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[[Image:2wie.png|left|200px]]
 
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==High-resolution structure of the rotor ring from a proton dependent ATP synthase==
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The line below this paragraph, containing "STRUCTURE_2wie", creates the "Structure Box" on the page.
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<StructureSection load='2wie' size='340' side='right'caption='[[2wie]], [[Resolution|resolution]] 2.13&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2wie]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Arthrospira_platensis Arthrospira platensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WIE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WIE FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.13&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CVM:CYMAL-4'>CVM</scene>, <scene name='pdbligand=FME:N-FORMYLMETHIONINE'>FME</scene></td></tr>
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{{STRUCTURE_2wie| PDB=2wie | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wie OCA], [https://pdbe.org/2wie PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wie RCSB], [https://www.ebi.ac.uk/pdbsum/2wie PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wie ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A5HEI4_ARTPT A5HEI4_ARTPT]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wi/2wie_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wie ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of the c-ring from the proton-coupled F1Fo ATP synthase from Spirulina platensis is shown at 2.1-A resolution. The ring includes 15 membrane-embedded c subunits forming an hourglass-shaped assembly. The structure demonstrates that proton translocation across the membrane entails protonation of a conserved glutamate located near the membrane center in the c subunit outer helix. The proton is locked in this site by a precise hydrogen bond network reminiscent of that in Na+-dependent ATP synthases. However, the structure suggests that the different coordination chemistry of the bound proton and the smaller curvature of the outer helix drastically enhance the selectivity of the H+ site against other cations, including H3O+. We propose a model for proton translocation whereby the c subunits remain in this proton-locked state when facing the membrane lipid. Proton exchange would occur in a more hydrophilic and electrostatically distinct environment upon contact with the a subunit interface.
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===HIGH-RESOLUTION STRUCTURE OF THE ROTOR RING FROM A PROTON DEPENDENT ATP SYNTHASE===
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High-resolution structure of the rotor ring of a proton-dependent ATP synthase.,Pogoryelov D, Yildiz O, Faraldo-Gomez JD, Meier T Nat Struct Mol Biol. 2009 Oct;16(10):1068-73. Epub 2009 Sep 27. PMID:19783985<ref>PMID:19783985</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2wie" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_19783985}}, adds the Publication Abstract to the page
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*[[ATPase 3D structures|ATPase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19783985 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19783985}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2WIE is a 5 chains structure of sequences from [http://en.wikipedia.org/wiki/Arthrospira_platensis Arthrospira platensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WIE OCA].
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==Reference==
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<ref group="xtra">PMID:19783985</ref><references group="xtra"/>
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[[Category: Arthrospira platensis]]
[[Category: Arthrospira platensis]]
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[[Category: Faraldo-Gomez, J D.]]
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[[Category: Large Structures]]
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[[Category: Meier, T.]]
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[[Category: Faraldo-Gomez JD]]
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[[Category: Pogoryelov, D.]]
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[[Category: Meier T]]
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[[Category: Yildiz, O.]]
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[[Category: Pogoryelov D]]
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[[Category: C-ring structure]]
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[[Category: Yildiz O]]
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[[Category: F1fo atp synthase rotor]]
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[[Category: Hydrogen ion transport]]
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[[Category: Hydrolase]]
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[[Category: Ion proton-translocation]]
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[[Category: Ion transport]]
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[[Category: Lipid-binding]]
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[[Category: Membrane]]
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[[Category: Membrane protein complex]]
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[[Category: Spirulina platensis]]
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[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 7 13:23:51 2009''
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Current revision

High-resolution structure of the rotor ring from a proton dependent ATP synthase

PDB ID 2wie

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