1p79

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(New page: 200px<br /><applet load="1p79" size="450" color="white" frame="true" align="right" spinBox="true" caption="1p79, resolution 1.10&Aring;" /> '''Crystal structure of...)
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[[Image:1p79.gif|left|200px]]<br /><applet load="1p79" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1p79, resolution 1.10&Aring;" />
 
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'''Crystal structure of a bulged RNA tetraplex: implications for a novel binding site in RNA tetraplex'''<br />
 
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==Overview==
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==Crystal structure of a bulged RNA tetraplex: implications for a novel binding site in RNA tetraplex==
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Bulges are an important structural motif in RNA and can be used as, recognition and interaction sites in RNA-protein interaction and RNA-RNA, interaction. Here we report the first crystal structure of a bulged RNA, tetraplex at 1.1 A resolution. The hexamer r(U)(BrdG)r(UGGU) forms a, parallel tetraplex with the uridine sandwiched by guanines bulging out., The bulged uridine adopts the syn glycosidic conformation and its O2 and, N3 atoms face outwards, serving as an effective recognition and, interaction site. The bulge formation both widens the groove width and, changes the groove hydrogen-bonding pattern on its 5' side. However, the, bulge does not make any bends or kinks in the tetraplex structure. The, present study demonstrates the dramatic difference between uridine and, guanine in forming tetraplex structure. In addition, both G(syn) tetrad, and G(anti) tetrad have been observed. They display the same base-pairing, pattern and similar C1'-C1' distance but different hydrogen-bonding, patterns in the groove.
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<StructureSection load='1p79' size='340' side='right'caption='[[1p79]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1p79]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P79 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P79 FirstGlance]. <br>
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1P79 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with K as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1P79 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p79 OCA], [https://pdbe.org/1p79 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p79 RCSB], [https://www.ebi.ac.uk/pdbsum/1p79 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p79 ProSAT]</span></td></tr>
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Crystal structure of a bulged RNA tetraplex at 1.1 a resolution: implications for a novel binding site in RNA tetraplex., Pan B, Xiong Y, Shi K, Sundaralingam M, Structure. 2003 Nov;11(11):1423-30. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14604532 14604532]
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</table>
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[[Category: Protein complex]]
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__TOC__
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[[Category: Pan, B.]]
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</StructureSection>
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[[Category: Shi, K.]]
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[[Category: Large Structures]]
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[[Category: Sundaralingam, M.]]
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[[Category: Pan B]]
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[[Category: Xiong, Y.]]
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[[Category: Shi K]]
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[[Category: K]]
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[[Category: Sundaralingam M]]
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[[Category: bulge]]
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[[Category: Xiong Y]]
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[[Category: rna]]
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[[Category: tetraplex]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 02:06:52 2007''
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Current revision

Crystal structure of a bulged RNA tetraplex: implications for a novel binding site in RNA tetraplex

PDB ID 1p79

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