2ke4

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{{Seed}}
 
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[[Image:2ke4.png|left|200px]]
 
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==The NMR structure of the TC10 and Cdc42 interacting domain of CIP4==
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The line below this paragraph, containing "STRUCTURE_2ke4", creates the "Structure Box" on the page.
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<StructureSection load='2ke4' size='340' side='right'caption='[[2ke4]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ke4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KE4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KE4 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ke4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ke4 OCA], [https://pdbe.org/2ke4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ke4 RCSB], [https://www.ebi.ac.uk/pdbsum/2ke4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ke4 ProSAT]</span></td></tr>
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{{STRUCTURE_2ke4| PDB=2ke4 | SCENE= }}
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</table>
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== Function ==
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===The NMR structure of the TC10 and Cdc42 interacting domain of CIP4===
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[https://www.uniprot.org/uniprot/CIP4_HUMAN CIP4_HUMAN] Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.<ref>PMID:11069762</ref> <ref>PMID:16326391</ref> <ref>PMID:16318909</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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2KE4 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KE4 OCA].
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ke/2ke4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ke4 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Inagaki, F.]]
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[[Category: Large Structures]]
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[[Category: Kanoh, D.]]
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[[Category: Inagaki F]]
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[[Category: Kobashigawa, Y.]]
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[[Category: Kanoh D]]
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[[Category: Kumeta, H.]]
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[[Category: Kobashigawa Y]]
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[[Category: Alternative splicing]]
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[[Category: Kumeta H]]
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[[Category: Cdc42]]
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[[Category: Cell membrane]]
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[[Category: Cip4]]
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[[Category: Coiled coil]]
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[[Category: Coiled-coil]]
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[[Category: Cytoplasm]]
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[[Category: Cytoskeleton]]
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[[Category: Endocytosis]]
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[[Category: Golgi apparatus]]
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[[Category: Lipid-binding]]
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[[Category: Lysosome]]
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[[Category: Membrane]]
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[[Category: Membrane protein]]
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[[Category: Phosphoprotein]]
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[[Category: Sh3 domain]]
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[[Category: Tc10]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 7 20:06:33 2009''
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Current revision

The NMR structure of the TC10 and Cdc42 interacting domain of CIP4

PDB ID 2ke4

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