3h9z

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{{Seed}}
 
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[[Image:3h9z.png|left|200px]]
 
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==Crystal structure of the IgE-Fc3-4 domains==
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The line below this paragraph, containing "STRUCTURE_3h9z", creates the "Structure Box" on the page.
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<StructureSection load='3h9z' size='340' side='right'caption='[[3h9z]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3h9z]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H9Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H9Z FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene></td></tr>
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{{STRUCTURE_3h9z| PDB=3h9z | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h9z OCA], [https://pdbe.org/3h9z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h9z RCSB], [https://www.ebi.ac.uk/pdbsum/3h9z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h9z ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IGHE_HUMAN IGHE_HUMAN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h9/3h9z_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3h9z ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structure of immunoglobulin E (IgE)-Fc(3-4) has been solved in three new crystal forms, providing 13 snapshots of the Fc conformation and revealing a diverse range of open-closed motions among subunit chains and dimers. A more detailed analysis of the open-to-closed motion of IgE-Fc(3-4) was possible with so many structures, and the new structures allow a more thorough examination of the flexibility of IgE-Fc and its implications for receptor binding. The existence of a hydrophobic pocket at the elbow region of the Fc appears to be conformation dependent and suggests a means of regulating the IgE-Fc conformation (and potentially receptor binding) with small molecules.
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===Crystal structure of the IgE-Fc3-4 domains===
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Conformational flexibility in immunoglobulin E-Fc 3-4 revealed in multiple crystal forms.,Wurzburg BA, Jardetzky TS J Mol Biol. 2009 Oct 16;393(1):176-90. Epub 2009 Aug 13. PMID:19682998<ref>PMID:19682998</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19682998}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3h9z" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19682998 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19682998}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3H9Z is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H9Z OCA].
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==Reference==
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<ref group="xtra">PMID:19682998</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Wurzburg, B A.]]
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[[Category: Large Structures]]
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[[Category: Disulfide bond]]
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[[Category: Wurzburg BA]]
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[[Category: Fc]]
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[[Category: Flexibility]]
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[[Category: Glycoprotein]]
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[[Category: Hydrophobic pocket]]
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[[Category: Ige]]
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[[Category: Immune system]]
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[[Category: Immunoglobin]]
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[[Category: Immunoglobulin c region]]
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[[Category: Immunoglobulin domain]]
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[[Category: Polymorphism]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 14 09:55:50 2009''
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Current revision

Crystal structure of the IgE-Fc3-4 domains

PDB ID 3h9z

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OCA

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