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3hon

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{{Seed}}
 
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[[Image:3hon.png|left|200px]]
 
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<!--
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==Crystal Structure of Human Collagen XVIII Trimerization Domain (cubic form)==
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The line below this paragraph, containing "STRUCTURE_3hon", creates the "Structure Box" on the page.
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<StructureSection load='3hon' size='340' side='right'caption='[[3hon]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3hon]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HON OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HON FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hon FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hon OCA], [https://pdbe.org/3hon PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hon RCSB], [https://www.ebi.ac.uk/pdbsum/3hon PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hon ProSAT]</span></td></tr>
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{{STRUCTURE_3hon| PDB=3hon | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/COIA1_HUMAN COIA1_HUMAN] Defects in COL18A1 are a cause of Knobloch syndrome type 1 (KNO1) [MIM:[https://omim.org/entry/267750 267750]. An autosomal recessive disorder defined by the occurrence of high myopia, vitreoretinal degeneration with retinal detachment, macular abnormalities and occipital encephalocele.<ref>PMID:10942434</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/COIA1_HUMAN COIA1_HUMAN] COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ho/3hon_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hon ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of Human Collagen XVIII Trimerization Domain (cubic form)===
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==See Also==
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*[[Collagen 3D structures|Collagen 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_19631658}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 19631658 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_19631658}}
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==Disease==
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Known disease associated with this structure: Knobloch syndrome, type 1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=120328 120328]]
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==About this Structure==
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3HON is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HON OCA].
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==Reference==
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<ref group="xtra">PMID:19631658</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bachinger, H P.]]
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[[Category: Large Structures]]
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[[Category: Boudko, S P.]]
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[[Category: Bachinger HP]]
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[[Category: Alternative promoter usage]]
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[[Category: Boudko SP]]
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[[Category: Alternative splicing]]
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[[Category: Cell adhesion]]
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[[Category: Collagen]]
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[[Category: Collagen triple helix]]
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[[Category: Collagen xviii]]
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[[Category: Disulfide bond]]
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[[Category: Extracellular matrix]]
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[[Category: Glycoprotein]]
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[[Category: Hydroxylation]]
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[[Category: Metal-binding]]
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[[Category: Multiplexin]]
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[[Category: Polymorphism]]
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[[Category: Protein binding]]
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[[Category: Secreted]]
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[[Category: Trimerization domain]]
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[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 14 09:58:40 2009''
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Current revision

Crystal Structure of Human Collagen XVIII Trimerization Domain (cubic form)

PDB ID 3hon

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