1l1v
From Proteopedia
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(New page: 200px<br /><applet load="1l1v" size="450" color="white" frame="true" align="right" spinBox="true" caption="1l1v" /> '''UNUSUAL ACTD/DNA_TA COMPLEX STRUCTURE'''<br ...) |
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| - | [[Image:1l1v.gif|left|200px]]<br /><applet load="1l1v" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1l1v" /> | ||
| - | '''UNUSUAL ACTD/DNA_TA COMPLEX STRUCTURE'''<br /> | ||
| - | == | + | ==UNUSUAL ACTD/DNA_TA COMPLEX STRUCTURE== |
| - | Many anticancer drugs interact directly with DNA to exert their biological | + | <StructureSection load='1l1v' size='340' side='right'caption='[[1l1v]]' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1l1v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_antibioticus Streptomyces antibioticus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L1V FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DVA:D-VALINE'>DVA</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=PXZ:2-AMINO-1,9-DICARBONYL-4,6-DIMETHYL-10-DEHYDRO-PHENOXAZIN-3-ONE'>PXZ</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l1v OCA], [https://pdbe.org/1l1v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l1v RCSB], [https://www.ebi.ac.uk/pdbsum/1l1v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l1v ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Many anticancer drugs interact directly with DNA to exert their biological functions. To date, all noncovalent, intercalating drugs interact with DNA exclusively by inserting their chromophores into base steps to form elongated and unwound duplex structures without disrupting the flanking base pairs. By using actinomycin D (ActD)-5'-GXC/CYG-5' complexes as examples, we have found a rather unusual interaction mode for the intercalated drug; the central Watson-Crick X/Y base pairs are looped out and displaced by the ActD chromophore. The looped-out bases are not disordered but interact perpendicularly with the base/chromophore and form specific H bonds with DNA. Such a complex structure provides intriguing insights into how ligand interacts with DNA and enlarges the repertoires for sequence-specific DNA recognition. | ||
| - | + | Looped out and perpendicular: deformation of Watson-Crick base pair associated with actinomycin D binding.,Chou SH, Chin KH, Chen FM Proc Natl Acad Sci U S A. 2002 May 14;99(10):6625-30. PMID:12011426<ref>PMID:12011426</ref> | |
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | [[Category: | + | <div class="pdbe-citations 1l1v" style="background-color:#fffaf0;"></div> |
| - | [[Category: Chen | + | == References == |
| - | [[Category: Chin | + | <references/> |
| - | [[Category: Chou | + | __TOC__ |
| - | + | </StructureSection> | |
| - | + | [[Category: Large Structures]] | |
| - | + | [[Category: Streptomyces antibioticus]] | |
| - | + | [[Category: Chen F-M]] | |
| - | + | [[Category: Chin K-H]] | |
| + | [[Category: Chou S-H]] | ||
Current revision
UNUSUAL ACTD/DNA_TA COMPLEX STRUCTURE
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