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1pef

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PEPTIDE F (EQLLKALEFLLKELLEKL), AMPHIPHILIC OCTADECAPEPTIDE

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Retrieved from "http://52.214.119.220/wiki/index.php/1pef"

Categories: Large Structures | Garavito RM | Taylor K | Yang NC

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-[[Image:1pef.jpg|left|200px]]<br /><applet load="1pef" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1pef, resolution 1.5&Aring;" />
-'''PEPTIDE F (EQLLKALEFLLKELLEKL), AMPHIPHILIC OCTADECAPEPTIDE'''<br />
-==Overview==
+==PEPTIDE F (EQLLKALEFLLKELLEKL), AMPHIPHILIC OCTADECAPEPTIDE==
-X-ray diffraction analysis at 1.5 A resolution has confirmed the helical, conformation of a de novo designed 18-residue peptide. However, the, crystal structure reveals the formation of continuous molecular layers of, parallel-packed amphiphilic helices as a result of much more extensive, helix-helix interactions than predicted. The crystal packing arrangement, by virtue of distinct antiparallel packing interactions, segregates the, polar and apolar surfaces of the helices into discrete and well-defined, interfacial regions. An extensive "ridges-into-grooves" interdigitation, characterizes the hydrophobic interface, whereas an extensive network of, salt bridges and hydrogen bonds dominates the corresponding hydrophilic, interface.
+<StructureSection load='1pef' size='340' side='right'caption='[[1pef]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
+== Structural highlights ==
-==About this Structure==
+<table><tr><td colspan='2'>[[1pef]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PEF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PEF FirstGlance]. <br>
-PEF is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1PEF OCA].
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pef OCA], [https://pdbe.org/1pef PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pef RCSB], [https://www.ebi.ac.uk/pdbsum/1pef PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pef ProSAT]</span></td></tr>
-==Reference==
+</table>
-A novel, multilayer structure of a helical peptide., Taylor KS, Lou MZ, Chin TM, Yang NC, Garavito RM, Protein Sci. 1996 Mar;5(3):414-21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8868477 8868477]
+__TOC__
-[[Category: Protein complex]]
+</StructureSection>
-[[Category: Garavito, R.M.]]
+[[Category: Large Structures]]
-[[Category: Taylor, K.]]
+[[Category: Garavito RM]]
-[[Category: Yang, N.C.]]
+[[Category: Taylor K]]
-[[Category: alpha-helical bundle]]
+[[Category: Yang NC]]
-[[Category: synthetic protein]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 02:23:28 2007''

1pef

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PEPTIDE F (EQLLKALEFLLKELLEKL), AMPHIPHILIC OCTADECAPEPTIDE

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