1xl6

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(New page: 200px<br /><applet load="1xl6" size="450" color="white" frame="true" align="right" spinBox="true" caption="1xl6, resolution 2.85&Aring;" /> '''Intermediate gating ...)
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[[Image:1xl6.jpg|left|200px]]<br /><applet load="1xl6" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1xl6, resolution 2.85&Aring;" />
 
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'''Intermediate gating structure 2 of the inwardly rectifying K+ channel KirBac3.1'''<br />
 
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==About this Structure==
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==Intermediate gating structure 2 of the inwardly rectifying K+ channel KirBac3.1==
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1XL6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Magnetospirillum_magnetotacticum Magnetospirillum magnetotacticum] with K, MG and SPM as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1XL6 OCA].
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<StructureSection load='1xl6' size='340' side='right'caption='[[1xl6]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
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[[Category: Magnetospirillum magnetotacticum]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[1xl6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Magnetospirillum_magnetotacticum Magnetospirillum magnetotacticum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XL6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XL6 FirstGlance]. <br>
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[[Category: Arrowsmith, C.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
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[[Category: Doyle, D.A.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SPM:SPERMINE'>SPM</scene></td></tr>
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[[Category: Edwards, A.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xl6 OCA], [https://pdbe.org/1xl6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xl6 RCSB], [https://www.ebi.ac.uk/pdbsum/1xl6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xl6 ProSAT]</span></td></tr>
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[[Category: Gulbis, J.M.]]
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</table>
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[[Category: Kuo, A.]]
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== Function ==
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[[Category: Smith, B.]]
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[https://www.uniprot.org/uniprot/IRK10_MAGMG IRK10_MAGMG] Inward rectifier potassium channel that mediates potassium uptake into the cell. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. The inward rectification may be achieved by the blockage of outward current by cytoplasmic divalent metal ions and polyamines. Complements an E.coli mutant that is defective in K(+) uptake.<ref>PMID:20876570</ref> <ref>PMID:20564790</ref> <ref>PMID:22231399</ref>
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[[Category: Sundstrom, M.]]
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== Evolutionary Conservation ==
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[[Category: K]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: MG]]
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Check<jmol>
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[[Category: SPM]]
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<jmolCheckbox>
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[[Category: integral membrane protein]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xl/1xl6_consurf.spt"</scriptWhenChecked>
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[[Category: inwardly rectifying k+ channel]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: ion channel]]
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xl6 ConSurf].
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<div style="clear:both"></div>
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 02:25:10 2007''
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==See Also==
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*[[Potassium channel 3D structures|Potassium channel 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Magnetospirillum magnetotacticum]]
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[[Category: Arrowsmith C]]
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[[Category: Doyle DA]]
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[[Category: Edwards A]]
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[[Category: Gulbis JM]]
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[[Category: Kuo A]]
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[[Category: Smith B]]
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[[Category: Sundstrom M]]

Current revision

Intermediate gating structure 2 of the inwardly rectifying K+ channel KirBac3.1

PDB ID 1xl6

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