3gww

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{{Seed}}
 
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[[Image:3gww.png|left|200px]]
 
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==Leucine transporter LeuT in complex with S-fluoxetine==
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The line below this paragraph, containing "STRUCTURE_3gww", creates the "Structure Box" on the page.
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<StructureSection load='3gww' size='340' side='right'caption='[[3gww]], [[Resolution|resolution]] 2.46&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3gww]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus_VF5 Aquifex aeolicus VF5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GWW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GWW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.46&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LEU:LEUCINE'>LEU</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SFX:(3S)-N-METHYL-3-PHENYL-3-[4-(TRIFLUOROMETHYL)PHENOXY]PROPAN-1-AMINE'>SFX</scene></td></tr>
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{{STRUCTURE_3gww| PDB=3gww | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gww OCA], [https://pdbe.org/3gww PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gww RCSB], [https://www.ebi.ac.uk/pdbsum/3gww PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gww ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/O67854_AQUAE O67854_AQUAE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gw/3gww_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gww ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Sertraline and fluoxetine are selective serotonin re-uptake inhibitors (SSRIs) that are widely prescribed to treat depression. They exert their effects by inhibiting the presynaptic plasma membrane serotonin transporter (SERT). All SSRIs possess halogen atoms at specific positions, which are key determinants for the drugs' specificity for SERT. For the SERT protein, however, the structural basis of its specificity for SSRIs is poorly understood. Here we report the crystal structures of LeuT, a bacterial SERT homolog, in complex with sertraline, R-fluoxetine or S-fluoxetine. The SSRI halogens all bind to exactly the same pocket within LeuT. Mutation at this halogen-binding pocket (HBP) in SERT markedly reduces the transporter's affinity for SSRIs but not for tricyclic antidepressants. Conversely, when the only nonconserved HBP residue in both norepinephrine and dopamine transporters is mutated into that found in SERT, their affinities for all the three SSRIs increase uniformly. Thus, the specificity of SERT for SSRIs is dependent largely on interaction of the drug halogens with the protein's HBP.
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===Leucine transporter LeuT in complex with S-fluoxetine===
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Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures.,Zhou Z, Zhen J, Karpowich NK, Law CJ, Reith ME, Wang DN Nat Struct Mol Biol. 2009 Jun;16(6):652-7. Epub 2009 May 10. PMID:19430461<ref>PMID:19430461</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3gww" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_19430461}}, adds the Publication Abstract to the page
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*[[Leucine transporter|Leucine transporter]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19430461 is the PubMed ID number.
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*[[Symporter 3D structures|Symporter 3D structures]]
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== References ==
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{{ABSTRACT_PUBMED_19430461}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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3GWW is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus_vf5 Aquifex aeolicus vf5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GWW OCA].
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[[Category: Aquifex aeolicus VF5]]
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[[Category: Large Structures]]
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==Reference==
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[[Category: Karpowich NK]]
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<ref group="xtra">PMID:19430461</ref><references group="xtra"/>
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[[Category: Law CJ]]
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[[Category: Aquifex aeolicus vf5]]
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[[Category: Reith MEA]]
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[[Category: Karpowich, N K.]]
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[[Category: Wang DN]]
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[[Category: Law, C J.]]
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[[Category: Zhen J]]
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[[Category: Reith, M E.A.]]
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[[Category: Zhou Z]]
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[[Category: Wang, D N.]]
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[[Category: Zhen, J.]]
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[[Category: Zhou, Z.]]
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[[Category: Antidepressant]]
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[[Category: Integral membrane protein]]
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[[Category: Neurotransmitter]]
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[[Category: Nss]]
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[[Category: Symport]]
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[[Category: Transmembrane]]
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[[Category: Transmembrane transport]]
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[[Category: Transport]]
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[[Category: Transport protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 21 09:44:01 2009''
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Current revision

Leucine transporter LeuT in complex with S-fluoxetine

PDB ID 3gww

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OCA

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