3g05

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{{Seed}}
 
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[[Image:3g05.jpg|left|200px]]
 
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==Crystal structure of N-terminal domain (2-550) of E.coli MnmG==
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The line below this paragraph, containing "STRUCTURE_3g05", creates the "Structure Box" on the page.
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<StructureSection load='3g05' size='340' side='right'caption='[[3g05]], [[Resolution|resolution]] 3.49&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3g05]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7_str._EDL933 Escherichia coli O157:H7 str. EDL933]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G05 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G05 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.49&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3g05| PDB=3g05 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g05 OCA], [https://pdbe.org/3g05 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g05 RCSB], [https://www.ebi.ac.uk/pdbsum/3g05 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g05 ProSAT], [https://www.topsan.org/Proteins/BSGI/3g05 TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MNMG_ECO57 MNMG_ECO57] NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g0/3g05_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3g05 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The MnmE-MnmG complex is involved in tRNA modification. We have determined the crystal structure of Escherichia coli MnmG at 2.4-A resolution, mutated highly conserved residues with putative roles in flavin adenine dinucleotide (FAD) or tRNA binding and MnmE interaction, and analyzed the effects of these mutations in vivo and in vitro. Limited trypsinolysis of MnmG suggests significant conformational changes upon FAD binding.
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===Crystal structure of N-terminal domain (2-550) of E.coli MnmG===
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Structure-function analysis of Escherichia coli MnmG (GidA), a highly conserved tRNA-modifying enzyme.,Shi R, Villarroya M, Ruiz-Partida R, Li Y, Proteau A, Prado S, Moukadiri I, Benitez-Paez A, Lomas R, Wagner J, Matte A, Velazquez-Campoy A, Armengod ME, Cygler M J Bacteriol. 2009 Dec;191(24):7614-9. Epub 2009 Oct 2. PMID:19801413<ref>PMID:19801413</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19801413}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3g05" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19801413 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19801413}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Escherichia coli O157:H7 str. EDL933]]
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3G05 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli_o157:h7_edl933 Escherichia coli o157:h7 edl933]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G05 OCA].
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[[Category: Large Structures]]
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[[Category: Cygler M]]
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==Reference==
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[[Category: Matte A]]
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<ref group="xtra">PMID:19801413</ref><references group="xtra"/>
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[[Category: Shi R]]
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[[Category: Escherichia coli o157:h7 edl933]]
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[[Category: BSGI, Montreal-Kingston Bacterial Structural Genomics Initiative.]]
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[[Category: Cygler, M.]]
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[[Category: Matte, A.]]
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[[Category: Shi, R.]]
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[[Category: Bsgi]]
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[[Category: Cytoplasm]]
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[[Category: Fad]]
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[[Category: Flavoprotein]]
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[[Category: Montreal-kingston bacterial structural genomics initiative]]
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[[Category: Nad]]
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[[Category: Rna binding protein]]
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[[Category: Structural genomic]]
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[[Category: Trna processing]]
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[[Category: Trna-modification enzyme]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 21 10:15:30 2009''
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Current revision

Crystal structure of N-terminal domain (2-550) of E.coli MnmG

PDB ID 3g05

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OCA

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