3gew

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{{Seed}}
 
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[[Image:3gew.jpg|left|200px]]
 
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==FaeE-FaeG chaperone-major pilin complex of F4 ad fimbriae==
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The line below this paragraph, containing "STRUCTURE_3gew", creates the "Structure Box" on the page.
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<StructureSection load='3gew' size='340' side='right'caption='[[3gew]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3gew]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GEW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GEW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3gew| PDB=3gew | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gew OCA], [https://pdbe.org/3gew PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gew RCSB], [https://www.ebi.ac.uk/pdbsum/3gew PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gew ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FAEE_ECOLX FAEE_ECOLX] Mediates assembly of pili by forming soluble multimeric complexes with pili subunits as an intermediate step in the assembly process. This protein is involved in K88 pili assembly. Protects pilin protein from proteolytic degradation by DegP and from premature polymerization.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ge/3gew_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gew ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Enterotoxigenic Escherichia coli expressing F4 fimbriae are the major cause of porcine colibacillosis and are responsible for significant death and morbidity in neonatal and postweaned piglets. Via the chaperone-usher pathway, F4 fimbriae are assembled into thin, flexible polymers mainly composed of the single-domain adhesin FaeG. The F4 fimbrial system has been labeled eccentric because the F4 pilins show some features distinct from the features of pilins of other chaperone-usher-assembled structures. In particular, FaeG is much larger than other pilins (27 versus approximately 17 kDa), grafting an additional carbohydrate binding domain on the common immunoglobulin-like core. Structural data of FaeG during different stages of the F4 fimbrial biogenesis process, combined with differential scanning calorimetry measurements, confirm the general principles of the donor strand complementation/exchange mechanisms taking place during pilus biogenesis via the chaperone-usher pathway.
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===FaeE-FaeG chaperone-major pilin complex of F4 ad fimbriae===
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Structural and thermodynamic characterization of pre- and postpolymerization states in the F4 fimbrial subunit FaeG.,Van Molle I, Moonens K, Garcia-Pino A, Buts L, De Kerpel M, Wyns L, Bouckaert J, De Greve H J Mol Biol. 2009 Dec 18;394(5):957-67. Epub 2009 Sep 30. PMID:19799915<ref>PMID:19799915</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3gew" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_19799915}}, adds the Publication Abstract to the page
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*[[Pilin 3D structures|Pilin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19799915 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19799915}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3GEW is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GEW OCA].
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==Reference==
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<ref group="xtra">PMID:19799915</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Bouckaert, J.]]
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[[Category: Large Structures]]
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[[Category: Buts, L.]]
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[[Category: Bouckaert J]]
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[[Category: Garcia-Pino, A.]]
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[[Category: Buts L]]
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[[Category: Greve, H De.]]
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[[Category: De Greve H]]
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[[Category: Molle, I Van.]]
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[[Category: Garcia-Pino A]]
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[[Category: Moonens, K.]]
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[[Category: Moonens K]]
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[[Category: Cell adhesion]]
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[[Category: Van Molle I]]
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[[Category: Chaperone]]
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[[Category: Fimbrium]]
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[[Category: Immunoglobulin domain]]
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[[Category: Immunoglobulin like fold]]
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[[Category: Periplasm]]
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[[Category: Plasmid]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 21 10:17:56 2009''
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Current revision

FaeE-FaeG chaperone-major pilin complex of F4 ad fimbriae

PDB ID 3gew

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