3fhu

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{{Seed}}
 
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[[Image:3fhu.jpg|left|200px]]
 
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==Crystal structure of type IV b pilin from Salmonella typhi==
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The line below this paragraph, containing "STRUCTURE_3fhu", creates the "Structure Box" on the page.
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<StructureSection load='3fhu' size='340' side='right'caption='[[3fhu]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3fhu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhi Salmonella enterica subsp. enterica serovar Typhi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FHU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FHU FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fhu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fhu OCA], [https://pdbe.org/3fhu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fhu RCSB], [https://www.ebi.ac.uk/pdbsum/3fhu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fhu ProSAT]</span></td></tr>
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{{STRUCTURE_3fhu| PDB=3fhu | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8Z1L1_SALTI Q8Z1L1_SALTI]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fh/3fhu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fhu ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The type IVb pilus of the enteropathogenic bacteria Salmonella typhi is a major adhesion factor during the entry of this pathogen into gastrointestinal epithelial cells. Its target of adhesion is a stretch of 10 residues from the first extracellular domain of cystic fibrosis transmembrane conductance regulator (CFTR). The crystal structure of the N-terminal 25 amino acid deleted S. typhi native PilS protein (DeltaPilS), which makes the pilus, was determined at 1.9 A resolution by the multiwavelength anomalous dispersion method. Also, the structure of the complex of DeltaPilS and a target CFTR peptide, determined at 1.8 A, confirms that residues 113-117 (NKEER) of CFTR are involved in binding with the pilin protein and gives us insight on the amino acids that are essential for binding. Furthermore, we have also explored the role of a conserved disulfide bridge in pilus formation. The subunit structure and assembly architecture are crucial for understanding pilus functions and designing suitable therapeutics against typhoid.
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===Crystal strcuture of type IV b pilin from Salmonella typhi===
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Structural basis of typhoid: Salmonella typhi type IVb pilin (PilS) and cystic fibrosis transmembrane conductance regulator interaction.,Balakrishna AM, Saxena AM, Mok HY, Swaminathan K Proteins. 2009 Nov 1;77(2):253-61. PMID:19626704<ref>PMID:19626704</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3fhu" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_19626704}}, adds the Publication Abstract to the page
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*[[Pilin|Pilin]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19626704 is the PubMed ID number.
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*[[Pilin 3D structures|Pilin 3D structures]]
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== References ==
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{{ABSTRACT_PUBMED_19626704}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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3FHU is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhi Salmonella enterica subsp. enterica serovar typhi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FHU OCA].
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[[Category: Large Structures]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhi]]
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==Reference==
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[[Category: Balakrishna AM]]
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<ref group="xtra">PMID:19626704</ref><references group="xtra"/>
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[[Category: Swaminathan K]]
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[[Category: Salmonella enterica subsp. enterica serovar typhi]]
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[[Category: Balakrishna, A M.]]
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[[Category: Swaminathan, K.]]
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[[Category: Cell adhesion]]
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[[Category: Crystal structure]]
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[[Category: Pilin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 21 10:22:33 2009''
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Current revision

Crystal structure of type IV b pilin from Salmonella typhi

PDB ID 3fhu

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