1d59

[[Image:1d59.gif|left|200px]]<br /><applet load="1d59" size="450" color="white" frame="true" align="right" spinBox="true"

caption="1d59, resolution 2.300&Aring;" />

'''CRYSTAL STRUCTURE OF 4-STRANDED OXYTRICHA TELOMERIC DNA'''<br />

==Overview==

The sequence d(GGGGTTTTGGGG) from the 3' overhang of the Oxytricha, telomere has been crystallized and its three-dimensional structure solved, to 2.5 A resolution. The oligonucleotide forms hairpins, two of which join, to make a four-stranded helical structure with the loops containing four, thymine residues at either end. The guanine residues are held together by, cyclic hydrogen bonding and an ion is located in the centre. The four, guanine residues in each segment have a glycosyl conformation that, alternates between anti and syn. There are two four-stranded molecules in, the asymmetric unit showing that the structure has some intrinsic, flexibility.

 

==About this Structure==

1D59 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1D59 OCA].

 

==Reference==

Crystal structure of four-stranded Oxytricha telomeric DNA., Kang C, Zhang X, Ratliff R, Moyzis R, Rich A, Nature. 1992 Mar 12;356(6365):126-31. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1545863 1545863]

[[Category: Protein complex]]

[[Category: Kang, C.]]

[[Category: Moyzis, R.]]

[[Category: Ratliff, R.]]

[[Category: Rich, A.]]

[[Category: Zhang, X.]]

[[Category: loop]]

[[Category: quadruple helix]]

[[Category: tetraplex]]

[[Category: u-dna]]