3it8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:01, 6 November 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:3it8.jpg|left|200px]]
 
-
<!--
+
==Crystal structure of TNF alpha complexed with a poxvirus MHC-related TNF binding protein==
-
The line below this paragraph, containing "STRUCTURE_3it8", creates the "Structure Box" on the page.
+
<StructureSection load='3it8' size='340' side='right'caption='[[3it8]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3it8]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Yaba-like_disease_virus Yaba-like disease virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IT8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IT8 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-
{{STRUCTURE_3it8| PDB=3it8 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3it8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3it8 OCA], [https://pdbe.org/3it8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3it8 RCSB], [https://www.ebi.ac.uk/pdbsum/3it8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3it8 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q9DHW0_YLDV Q9DHW0_YLDV]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/it/3it8_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3it8 ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The poxvirus 2L protein binds tumor necrosis factor-alpha (TNFalpha) to inhibit host antiviral and immune responses. The 2.8-A 2L-TNFalpha structure reveals three symmetrically arranged 2L molecules per TNFalpha trimer. 2L resembles class I major histocompatibility complex (MHC) molecules but lacks a peptide-binding groove and beta2-microglobulin light chain. Overlap between the 2L and host TNF receptor-binding sites on TNFalpha rationalizes 2L inhibition of TNFalpha-TNF receptor interactions and prevention of TNFalpha-induced immune responses.
-
===Crystal structure of TNF alpha complexed with a poxvirus MHC-related TNF binding protein===
+
Crystal structure of TNFalpha complexed with a poxvirus MHC-related TNF binding protein.,Yang Z, West AP Jr, Bjorkman PJ Nat Struct Mol Biol. 2009 Nov;16(11):1189-91. Epub 2009 Oct 18. PMID:19838188<ref>PMID:19838188</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 3it8" style="background-color:#fffaf0;"></div>
-
==Disease==
+
==See Also==
-
Known disease associated with this structure: Asthma, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191160 191160]], Dementia, vascular, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191160 191160]], Malaria, cerebral, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191160 191160]], Migraine without aura, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191160 191160]], Septic shock, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191160 191160]]
+
*[[Tumor necrosis factor 3D structures|Tumor necrosis factor 3D structures]]
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
3IT8 is a 12 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IT8 OCA].
+
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Viruses]]
+
[[Category: Large Structures]]
-
[[Category: Bjorkman, P J.]]
+
[[Category: Yaba-like disease virus]]
-
[[Category: Jr., A P.West.]]
+
[[Category: Bjorkman PJ]]
-
[[Category: Yang, Z.]]
+
[[Category: West Jr AP]]
-
[[Category: Cell membrane]]
+
[[Category: Yang Z]]
-
[[Category: Cytokine]]
+
-
[[Category: Disulfide bond]]
+
-
[[Category: Glycoprotein]]
+
-
[[Category: Immune system]]
+
-
[[Category: Lipoprotein]]
+
-
[[Category: Membrane]]
+
-
[[Category: Mhc class i homolog]]
+
-
[[Category: Myristate]]
+
-
[[Category: Phosphoprotein]]
+
-
[[Category: Polymorphism]]
+
-
[[Category: Secreted]]
+
-
[[Category: Signal-anchor]]
+
-
[[Category: Transmembrane]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 21 10:39:19 2009''
+

Current revision

Crystal structure of TNF alpha complexed with a poxvirus MHC-related TNF binding protein

PDB ID 3it8

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3it8"
Personal tools