1tqx

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(New page: 200px<br /><applet load="1tqx" size="450" color="white" frame="true" align="right" spinBox="true" caption="1tqx, resolution 2.00&Aring;" /> '''Crystal Structure of...)
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[[Image:1tqx.gif|left|200px]]<br /><applet load="1tqx" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1tqx, resolution 2.00&Aring;" />
 
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'''Crystal Structure of Pfal009167 A Putative D-Ribulose 5-Phosphate 3-Epimerase from P.falciparum'''<br />
 
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==Overview==
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==Crystal Structure of Pfal009167 A Putative D-Ribulose 5-Phosphate 3-Epimerase from P.falciparum==
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The crystal structure of Pfal009167AAA, a putative ribulose 5-phosphate, 3-epimerase (PfalRPE) from Plasmodium falciparum, has been determined to 2, A resolution. RPE represents an exciting potential drug target for, developing antimalarials because it is involved in the shikimate and the, pentose phosphate pathways. The structure is a classic TIM-barrel fold. A, coordinated Zn ion and a bound sulfate ion in the active site of the, enzyme allow for a greater understanding of the mechanism of action of, this enzyme. This structure is solved in the framework of the Structural, Genomics of Pathogenic Protozoa (SGPP) consortium.
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<StructureSection load='1tqx' size='340' side='right'caption='[[1tqx]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1tqx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TQX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tqx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tqx OCA], [https://pdbe.org/1tqx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tqx RCSB], [https://www.ebi.ac.uk/pdbsum/1tqx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tqx ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8I5L3_PLAF7 Q8I5L3_PLAF7]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tq/1tqx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tqx ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of Pfal009167AAA, a putative ribulose 5-phosphate 3-epimerase (PfalRPE) from Plasmodium falciparum, has been determined to 2 A resolution. RPE represents an exciting potential drug target for developing antimalarials because it is involved in the shikimate and the pentose phosphate pathways. The structure is a classic TIM-barrel fold. A coordinated Zn ion and a bound sulfate ion in the active site of the enzyme allow for a greater understanding of the mechanism of action of this enzyme. This structure is solved in the framework of the Structural Genomics of Pathogenic Protozoa (SGPP) consortium.
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==About this Structure==
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Structure of a ribulose 5-phosphate 3-epimerase from Plasmodium falciparum.,Caruthers J, Bosch J, Buckner F, Van Voorhis W, Myler P, Worthey E, Mehlin C, Boni E, DeTitta G, Luft J, Lauricella A, Kalyuzhniy O, Anderson L, Zucker F, Soltis M, Hol WG Proteins. 2006 Feb 1;62(2):338-42. PMID:16304640<ref>PMID:16304640</ref>
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1TQX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum_3d7 Plasmodium falciparum 3d7] with SO4 and ZN as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1TQX OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Structure of a ribulose 5-phosphate 3-epimerase from Plasmodium falciparum., Caruthers J, Bosch J, Buckner F, Van Voorhis W, Myler P, Worthey E, Mehlin C, Boni E, DeTitta G, Luft J, Lauricella A, Kalyuzhniy O, Anderson L, Zucker F, Soltis M, Hol WG, Proteins. 2006 Feb 1;62(2):338-42. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16304640 16304640]
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</div>
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[[Category: Plasmodium falciparum 3d7]]
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<div class="pdbe-citations 1tqx" style="background-color:#fffaf0;"></div>
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[[Category: Single protein]]
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== References ==
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[[Category: Bosch, J.]]
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<references/>
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[[Category: Caruthers, J.]]
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__TOC__
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[[Category: Hol, W.G.J.]]
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</StructureSection>
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[[Category: SGPP, Structural.Genomics.of.Pathogenic.Protozoa.Consortium.]]
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[[Category: Large Structures]]
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[[Category: SO4]]
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[[Category: Plasmodium falciparum 3D7]]
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[[Category: ZN]]
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[[Category: Bosch J]]
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[[Category: protein structure initiative]]
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[[Category: Caruthers J]]
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[[Category: psi]]
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[[Category: Hol WGJ]]
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[[Category: ribulose phosphate epimerase]]
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[[Category: sgpp]]
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[[Category: structural genomics]]
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[[Category: structural genomics of pathogenic protozoa consortium]]
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[[Category: tim barrel]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 02:35:45 2007''
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Current revision

Crystal Structure of Pfal009167 A Putative D-Ribulose 5-Phosphate 3-Epimerase from P.falciparum

PDB ID 1tqx

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