1d7m

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(New page: 200px<br /><applet load="1d7m" size="450" color="white" frame="true" align="right" spinBox="true" caption="1d7m, resolution 2.70&Aring;" /> '''COILED-COIL DIMERIZA...)
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[[Image:1d7m.gif|left|200px]]<br /><applet load="1d7m" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1d7m, resolution 2.70&Aring;" />
 
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'''COILED-COIL DIMERIZATION DOMAIN FROM CORTEXILLIN I'''<br />
 
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==Overview==
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==COILED-COIL DIMERIZATION DOMAIN FROM CORTEXILLIN I==
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BACKGROUND: The parallel two-stranded alpha-helical coiled coil is the, most frequently encountered subunit-oligomerization motif in proteins. The, simplicity and regularity of this motif have made it an attractive system, to explore some of the fundamental principles of protein folding and, stability and to test the principles of de novo design. RESULTS: The X-ray, crystal structure of the 18-heptad-repeat alpha-helical coiled-coil domain, of the actin-bundling protein cortexillin I from Dictyostelium discoideum, is a tightly packed parallel two-stranded alpha-helical coiled coil. It, harbors a distinct 14-residue sequence motif that is essential for, coiled-coil formation, and is a prerequisite for the assembly of, cortexillin I. The atomic structure reveals novel types of ionic, coiled-coil interactions. In particular, the structure shows that a, characteristic interhelical and intrahelical salt-bridge pattern, in, combination with the hydrophobic interactions occurring at the dimer, interface, is the key structural feature of its coiled-coil trigger site., CONCLUSIONS: The knowledge gained from the structure could be used in the, de novo design of alpha-helical coiled coils for applications such as, two-stage drug targeting and delivery systems, and in the design of coiled, coils as templates for combinatorial helical libraries in drug discovery, and as synthetic carrier molecules.
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<StructureSection load='1d7m' size='340' side='right'caption='[[1d7m]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1d7m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D7M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D7M FirstGlance]. <br>
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1D7M is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1D7M OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d7m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d7m OCA], [https://pdbe.org/1d7m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d7m RCSB], [https://www.ebi.ac.uk/pdbsum/1d7m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d7m ProSAT]</span></td></tr>
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==Reference==
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</table>
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The coiled-coil trigger site of the rod domain of cortexillin I unveils a distinct network of interhelical and intrahelical salt bridges., Burkhard P, Kammerer RA, Steinmetz MO, Bourenkov GP, Aebi U, Structure. 2000 Mar 15;8(3):223-30. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10745004 10745004]
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== Function ==
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[https://www.uniprot.org/uniprot/CTXA_DICDI CTXA_DICDI] Acting-bundling protein. When linked to F-actin the actin filaments form preferentially anti-parallel bundles that associate into meshworks. Plays a major role in cytokinesis. Negatively regulates cortical localization of rapgap1.<ref>PMID:18039932</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Dictyostelium discoideum]]
[[Category: Dictyostelium discoideum]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Aebi, U.]]
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[[Category: Aebi U]]
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[[Category: Bourenkov, G.P.]]
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[[Category: Bourenkov GP]]
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[[Category: Burkhard, P.]]
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[[Category: Burkhard P]]
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[[Category: Kammerer, R.A.]]
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[[Category: Kammerer RA]]
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[[Category: Steinmetz, M.O.]]
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[[Category: Steinmetz MO]]
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[[Category: alpha helix]]
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[[Category: coiled-coil]]
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[[Category: coiled-coil trigger site]]
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[[Category: dimerization]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 02:40:30 2007''
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Current revision

COILED-COIL DIMERIZATION DOMAIN FROM CORTEXILLIN I

PDB ID 1d7m

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