3hve

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{{Seed}}
 
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[[Image:3hve.jpg|left|200px]]
 
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==Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases: GigaxoninBTB/3-box==
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The line below this paragraph, containing "STRUCTURE_3hve", creates the "Structure Box" on the page.
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<StructureSection load='3hve' size='340' side='right'caption='[[3hve]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3hve]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HVE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HVE FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_3hve| PDB=3hve | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hve OCA], [https://pdbe.org/3hve PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hve RCSB], [https://www.ebi.ac.uk/pdbsum/3hve PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hve ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/GAN_HUMAN GAN_HUMAN] Defects in GAN are the cause of giant axonal neuropathy (GAN) [MIM:[https://omim.org/entry/256850 256850]. GAN is a severe autosomal recessive sensorimotor neuropathy affecting both the peripheral nerves and the central nervous system. It is characterized by neurofilament accumulation, leading to segmental distention of axons.<ref>PMID:16303566</ref> <ref>PMID:11062483</ref> <ref>PMID:11971098</ref> <ref>PMID:12655563</ref> <ref>PMID:17578852</ref> <ref>PMID:17587580</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/GAN_HUMAN GAN_HUMAN] Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. Substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB. Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival.<ref>PMID:12147674</ref> <ref>PMID:14528312</ref> <ref>PMID:16303566</ref> <ref>PMID:15983046</ref> <ref>PMID:16227972</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hv/3hve_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hve ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In the largest E3 ligase subfamily, Cul3 binds a BTB domain, and an associated protein-interaction domain such as MATH recruits substrates for ubiquitination. Here, we present biochemical and structural analyses of the MATH-BTB protein, SPOP. We define a SPOP-binding consensus (SBC) and determine structures revealing recognition of SBCs from the phosphatase Puc, the transcriptional regulator Ci, and the chromatin component MacroH2A. We identify a dimeric SPOP-Cul3 assembly involving a conserved helical structure C-terminal of BTB domains, which we call "3-box" due to its facilitating Cul3 binding and its resemblance to F-/SOCS-boxes in other cullin-based E3s. Structural flexibility between the substrate-binding MATH and Cul3-binding BTB/3-box domains potentially allows a SPOP dimer to engage multiple SBCs found within a single substrate, such as Puc. These studies provide a molecular understanding of how MATH-BTB proteins recruit substrates to Cul3 and how their dimerization and conformational variability may facilitate avid interactions with diverse substrates.
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===Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases: GigaxoninBTB/3-box===
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Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases.,Zhuang M, Calabrese MF, Liu J, Waddell MB, Nourse A, Hammel M, Miller DJ, Walden H, Duda DM, Seyedin SN, Hoggard T, Harper JW, White KP, Schulman BA Mol Cell. 2009 Oct 9;36(1):39-50. PMID:19818708<ref>PMID:19818708</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3hve" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_19818708}}, adds the Publication Abstract to the page
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*[[Kelch-like protein 3D structures|Kelch-like protein 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19818708 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19818708}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3HVE is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HVE OCA].
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==Reference==
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<ref group="xtra">PMID:19818708</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Schulman, B A.]]
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[[Category: Large Structures]]
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[[Category: Zhuang, M.]]
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[[Category: Schulman BA]]
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[[Category: Cytoplasm]]
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[[Category: Zhuang M]]
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[[Category: Cytoskeleton]]
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[[Category: Disease mutation]]
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[[Category: Gigaxonin]]
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[[Category: Kelch repeat]]
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[[Category: Neurodegeneration]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Protein binding]]
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[[Category: Ubiquitin]]
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[[Category: Ubl conjugation]]
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[[Category: Ubl conjugation pathway]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 28 13:18:52 2009''
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Current revision

Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases: GigaxoninBTB/3-box

PDB ID 3hve

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