3a2w

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{{Seed}}
 
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[[Image:3a2w.jpg|left|200px]]
 
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==Peroxiredoxin (C50S) from Aeropytum pernix K1 (peroxide-bound form)==
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The line below this paragraph, containing "STRUCTURE_3a2w", creates the "Structure Box" on the page.
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<StructureSection load='3a2w' size='340' side='right'caption='[[3a2w]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3a2w]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Aeropyrum_pernix_K1 Aeropyrum pernix K1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A2W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A2W FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PER:PEROXIDE+ION'>PER</scene></td></tr>
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{{STRUCTURE_3a2w| PDB=3a2w | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a2w OCA], [https://pdbe.org/3a2w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a2w RCSB], [https://www.ebi.ac.uk/pdbsum/3a2w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a2w ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TDXH_AERPE TDXH_AERPE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a2/3a2w_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3a2w ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Peroxiredoxin (Prx) reduces hydrogen peroxide and alkyl peroxides to water and corresponding alcohols, respectively. The reaction is dependent on a peroxidatic cysteine, whose sulphur atom nucleophilically attacks one of the oxygen atoms of the peroxide substrate. In spite of the many structural studies that have been carried out on this reaction, the tertiary structure of the hydrogen peroxide-bound form of Prx has not been elucidated. In this paper, we report the crystal structure of Prx from Aeropyrum pernix K1 in the peroxide-bound form. The conformation of the polypeptide chain is the same as that in the reduced apo-form. The hydrogen peroxide molecule is in close contact with the peroxidatic Cys50 and the neighbouring Thr47 and Arg126 side chain atoms, as well as with the main chain nitrogen atoms of Val49 and Cys50. Bound peroxide was also observed in the mutant C50S, in which the peroxidatic cysteine was replaced by serine. Therefore, the sulphur atom of the peroxidatic cysteine is not essential for peroxide binding, although it enhances the binding affinity. Hydrogen peroxide binds to the protein so that it fills the active site pocket. This study provides insight into the early stage of the Prx reaction.
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===Peroxiredoxin (C50S) from Aeropytum pernix K1 (peroxide-bound form)===
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Crystal structure of peroxiredoxin from Aeropyrum pernix K1 complexed with its substrate, hydrogen peroxide.,Nakamura T, Kado Y, Yamaguchi T, Matsumura H, Ishikawa K, Inoue T J Biochem. 2010 Jan;147(1):109-15. Epub 2009 Oct 9. PMID:19819903<ref>PMID:19819903</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19819903}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3a2w" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19819903 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19819903}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Aeropyrum pernix K1]]
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3A2W is a 10 chains structure of sequences from [http://en.wikipedia.org/wiki/Aeropyrum_pernix_k1 Aeropyrum pernix k1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A2W OCA].
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[[Category: Large Structures]]
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[[Category: Inoue T]]
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==Reference==
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[[Category: Ishikawa K]]
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<ref group="xtra">PMID:19819903</ref><references group="xtra"/>
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[[Category: Kado Y]]
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[[Category: Aeropyrum pernix k1]]
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[[Category: Matsumura H]]
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[[Category: Peroxiredoxin]]
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[[Category: Nakamura T]]
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[[Category: Inoue, T.]]
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[[Category: Yamaguchi F]]
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[[Category: Ishikawa, K.]]
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[[Category: Kado, Y.]]
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[[Category: Matsumura, H.]]
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[[Category: Nakamura, T.]]
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[[Category: Yamaguchi, F.]]
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[[Category: Antioxidant]]
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[[Category: Hydrogen peroxide]]
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[[Category: Oxidoreductase]]
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[[Category: Peroxiredoxin]]
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[[Category: Redox-active center]]
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[[Category: Thioredoxin peroxidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 28 13:28:38 2009''
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Current revision

Peroxiredoxin (C50S) from Aeropytum pernix K1 (peroxide-bound form)

PDB ID 3a2w

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