3cm1

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{{Seed}}
 
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[[Image:3cm1.png|left|200px]]
 
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==Crystal structure of SsgA-like sporulation-specific cell division protein (YP_290167.1) from Thermobifida fusca YX-ER1 at 2.60 A resolution==
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The line below this paragraph, containing "STRUCTURE_3cm1", creates the "Structure Box" on the page.
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<StructureSection load='3cm1' size='340' side='right'caption='[[3cm1]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3cm1]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermobifida_fusca_YX Thermobifida fusca YX]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CM1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CM1 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_3cm1| PDB=3cm1 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cm1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cm1 OCA], [https://pdbe.org/3cm1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cm1 RCSB], [https://www.ebi.ac.uk/pdbsum/3cm1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cm1 ProSAT], [https://www.topsan.org/Proteins/JCSG/3cm1 TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SSGB_THEFY SSGB_THEFY] Involved in sporulation-specific cell division (PubMed:19567872). Required for early stages of sporulation. Important in the process of growth cessation prior to sporulation-specific cell division. Recruits cell division protein FtsZ to the future septum sites and tethers the contractile ring structure (Z ring) to the cytoplasmic membrane during sporulation (By similarity). Stimulates polymerization and filament length of FtsZ in vitro (PubMed:21205868).[UniProtKB:Q9L268]<ref>PMID:19567872</ref> <ref>PMID:21205868</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cm/3cm1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cm1 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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SsgA-like proteins (SALPs) are a family of homologous cell division-related proteins that occur exclusively in morphologically complex actinomycetes. We show that SsgB, a subfamily of SALPs, is the archetypal SALP that is functionally conserved in all sporulating actinomycetes. Sporulation-specific cell division of Streptomyces coelicolor ssgB mutants is restored by introduction of distant ssgB orthologues from other actinomycetes. Interestingly, the number of septa (and spores) of the complemented null mutants is dictated by the specific ssgB orthologue that is expressed. The crystal structure of the SsgB from Thermobifida fusca was determined at 2.6 A resolution and represents the first structure for this family. The structure revealed similarities to a class of eukaryotic "whirly" single-stranded DNA/RNA-binding proteins. However, the electro-negative surface of the SALPs suggests that neither SsgB nor any of the other SALPs are likely to interact with nucleotide substrates. Instead, we show that a conserved hydrophobic surface is likely to be important for SALP function and suggest that proteins are the likely binding partners.
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===Crystal structure of SsgA-like sporulation-specific cell division protein (YP_290167.1) from Thermobifida fusca YX-ER1 at 2.60 A resolution===
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Structural and functional characterizations of SsgB, a conserved activator of developmental cell division in morphologically complex actinomycetes.,Xu Q, Traag BA, Willemse J, McMullan D, Miller MD, Elsliger MA, Abdubek P, Astakhova T, Axelrod HL, Bakolitsa C, Carlton D, Chen C, Chiu HJ, Chruszcz M, Clayton T, Das D, Deller MC, Duan L, Ellrott K, Ernst D, Farr CL, Feuerhelm J, Grant JC, Grzechnik A, Grzechnik SK, Han GW, Jaroszewski L, Jin KK, Klock HE, Knuth MW, Kozbial P, Krishna SS, Kumar A, Marciano D, Minor W, Mommaas AM, Morse AT, Nigoghossian E, Nopakun A, Okach L, Oommachen S, Paulsen J, Puckett C, Reyes R, Rife CL, Sefcovic N, Tien HJ, Trame CB, van den Bedem H, Wang S, Weekes D, Hodgson KO, Wooley J, Deacon AM, Godzik A, Lesley SA, Wilson IA, van Wezel GP J Biol Chem. 2009 Sep 11;284(37):25268-79. Epub 2009 Jun 30. PMID:19567872<ref>PMID:19567872</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19567872}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3cm1" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19567872 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19567872}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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3CM1 is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Thermobifida_fusca_yx Thermobifida fusca yx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CM1 OCA].
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[[Category: Thermobifida fusca YX]]
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[[Category: Chruszcz M]]
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==Reference==
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[[Category: Minor W]]
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<ref group="xtra">PMID:19567872</ref><references group="xtra"/>
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[[Category: Wang S]]
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[[Category: Thermobifida fusca yx]]
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[[Category: Chruszcz, M.]]
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[[Category: JCSG, Joint Center for Structural Genomics.]]
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[[Category: Minor, W.]]
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[[Category: Wang, S.]]
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[[Category: Cell cycle]]
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[[Category: Jcsg]]
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[[Category: Joint center for structural genomic]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-2]]
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[[Category: Ssga]]
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[[Category: Ssga-like sporulation-specific cell division protein]]
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[[Category: Streptomyces sporulation and cell division protein]]
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[[Category: Structural genomic]]
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[[Category: Yp_290167 1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 28 13:38:02 2009''
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Current revision

Crystal structure of SsgA-like sporulation-specific cell division protein (YP_290167.1) from Thermobifida fusca YX-ER1 at 2.60 A resolution

PDB ID 3cm1

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