3jro

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{{Seed}}
 
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[[Image:3jro.jpg|left|200px]]
 
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==NUP84-NUP145C-SEC13 edge element of the NPC lattice==
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The line below this paragraph, containing "STRUCTURE_3jro", creates the "Structure Box" on the page.
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<StructureSection load='3jro' size='340' side='right'caption='[[3jro]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3jro]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JRO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JRO FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.004&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_3jro| PDB=3jro | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jro OCA], [https://pdbe.org/3jro PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jro RCSB], [https://www.ebi.ac.uk/pdbsum/3jro PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jro ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jr/3jro_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jro ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Nuclear pore complexes (NPCs) facilitate all nucleocytoplasmic transport. These massive protein assemblies are modular, with a stable structural scaffold supporting more dynamically attached components. The scaffold is made from multiple copies of the heptameric Y complex and the heteromeric Nic96 complex. We previously showed that members of these core subcomplexes specifically share an ACE1 fold with Sec31 of the COPII vesicle coat, and we proposed a lattice model for the NPC based on this commonality. Here we present the crystal structure of the heterotrimeric 134-kDa complex of Nup84-Nup145C-Sec13 of the Y complex. The heterotypic ACE1 interaction of Nup84 and Nup145C is analogous to the homotypic ACE1 interaction of Sec31 that forms COPII lattice edge elements and is inconsistent with the alternative 'fence-like' NPC model. We construct a molecular model of the Y complex and compare the architectural principles of COPII and NPC lattices.
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===NUP84-NUP145C-SEC13 edge element of the NPC lattice===
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Molecular architecture of the Nup84-Nup145C-Sec13 edge element in the nuclear pore complex lattice.,Brohawn SG, Schwartz TU Nat Struct Mol Biol. 2009 Nov;16(11):1173-7. Epub 2009 Oct 25. PMID:19855394<ref>PMID:19855394</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3jro" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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3JRO is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JRO OCA].
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*[[Nucleoporin 3D structures|Nucleoporin 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Brohawn, S G.]]
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[[Category: Brohawn SG]]
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[[Category: Schwartz, T U.]]
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[[Category: Schwartz TU]]
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[[Category: Autocatalytic cleavage]]
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[[Category: Cytoplasmic vesicle]]
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[[Category: Endoplasmic reticulum]]
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[[Category: Er-golgi transport]]
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[[Category: Hydrolase]]
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[[Category: Membrane]]
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[[Category: Mrna transport]]
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[[Category: Nuclear pore complex]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Protein complex]]
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[[Category: Protein transport]]
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[[Category: Structural protein]]
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[[Category: Translocation]]
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[[Category: Transport]]
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[[Category: Transport protein]]
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[[Category: Wd repeat]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 28 14:00:12 2009''
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Current revision

NUP84-NUP145C-SEC13 edge element of the NPC lattice

PDB ID 3jro

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