3fv3

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{{Seed}}
 
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[[Image:3fv3.png|left|200px]]
 
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==Secreted aspartic protease 1 from Candida parapsilosis in complex with pepstatin A==
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The line below this paragraph, containing "STRUCTURE_3fv3", creates the "Structure Box" on the page.
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<StructureSection load='3fv3' size='340' side='right'caption='[[3fv3]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3fv3]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_parapsilosis Candida parapsilosis] and [https://en.wikipedia.org/wiki/Streptomyces_argenteolus_subsp._toyonakensis Streptomyces argenteolus subsp. toyonakensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FV3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FV3 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IVA:ISOVALERIC+ACID'>IVA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=STA:STATINE'>STA</scene></td></tr>
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{{STRUCTURE_3fv3| PDB=3fv3 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fv3 OCA], [https://pdbe.org/3fv3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fv3 RCSB], [https://www.ebi.ac.uk/pdbsum/3fv3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fv3 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CARP1_CANPA CARP1_CANPA]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fv/3fv3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fv3 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Opportunistic pathogens of the genus Candida cause infections representing a major threat to long-term survival of immunocompromised patients. Virulence of the Candida pathogens is enhanced by production of extracellular proteolytic enzymes and secreted aspartic proteases (Saps) are therefore studied as potential virulence factors and possible targets for therapeutic drug design. Candida parapsilosis is less invasive than C. albicans, however, it is one of the leading causative agents of yeast infections. We report three-dimensional crystal structure of Sapp1p from C. parapsilosis in complex with pepstatin A, the classical inhibitor of aspartic proteases. The structure of Sapp1p was determined from protein isolated from its natural source and represents the first structure of Sap from C. parapsilosis. Overall fold and topology of Sapp1p is very similar to the archetypic fold of monomeric aspartic protease family and known structures of Sap isoenzymes from C. albicans and Sapt1p from C. tropicalis. Structural comparison revealed noticeable differences in the structure of loops surrounding the active site. This resulted in differential character, shape, and size of the substrate binding site explaining divergent substrate specificities and inhibitor affinities. Determination of structures of Sap isoenzymes from various species might contribute to the development of new Sap-specific inhibitors.
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===Secreted aspartic protease 1 from Candida parapsilosis in complex with pepstatin A===
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The crystal structure of the secreted aspartic protease 1 from Candida parapsilosis in complex with pepstatin A.,Dostal J, Brynda J, Hruskova-Heidingsfeldova O, Sieglova I, Pichova I, Rezacova P J Struct Biol. 2009 Aug;167(2):145-52. Epub 2009 May 3. PMID:19401235<ref>PMID:19401235</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19401235}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3fv3" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19401235 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19401235}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3FV3 is a 16 chains structure of sequences from [http://en.wikipedia.org/wiki/Candida_parapsilosis Candida parapsilosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FV3 OCA].
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==Reference==
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<ref group="xtra">PMID:19401235</ref><references group="xtra"/>
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[[Category: Candida parapsilosis]]
[[Category: Candida parapsilosis]]
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[[Category: Candidapepsin]]
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[[Category: Large Structures]]
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[[Category: Brynda, J.]]
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[[Category: Streptomyces argenteolus subsp. toyonakensis]]
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[[Category: Dostal, J.]]
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[[Category: Brynda J]]
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[[Category: Hruskova-Heidingsfeldova, O.]]
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[[Category: Dostal J]]
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[[Category: Pichova, I.]]
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[[Category: Hruskova-Heidingsfeldova O]]
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[[Category: Rezacova, P.]]
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[[Category: Pichova I]]
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[[Category: Sieglova, I.]]
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[[Category: Rezacova P]]
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[[Category: Hydrolase]]
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[[Category: Sieglova I]]
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[[Category: Pepstatin some]]
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[[Category: Secreted aspartic protease]]
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[[Category: Virulence factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 28 14:17:59 2009''
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Current revision

Secreted aspartic protease 1 from Candida parapsilosis in complex with pepstatin A

PDB ID 3fv3

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