3jyu

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{{Seed}}
 
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[[Image:3jyu.png|left|200px]]
 
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==Crystal structure of the N-terminal domains of the ubiquitin specific peptidase 4 (USP4)==
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The line below this paragraph, containing "STRUCTURE_3jyu", creates the "Structure Box" on the page.
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<StructureSection load='3jyu' size='340' side='right'caption='[[3jyu]], [[Resolution|resolution]] 2.37&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3jyu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JYU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JYU FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.37&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PS:3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE'>1PS</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_3jyu| PDB=3jyu | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jyu OCA], [https://pdbe.org/3jyu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jyu RCSB], [https://www.ebi.ac.uk/pdbsum/3jyu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jyu ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/UBP4_MOUSE UBP4_MOUSE] Deubiquitinating enzyme that removes conjugated ubiquitin from target proteins (By similarity). Deubiquitinates PDPK1 (By similarity). Deubiquitinates TRIM21 (By similarity). Deubiquitinates receptor ADORA2A which increases the amount of functional receptor at the cell surface (By similarity). Deubiquitinates HAS2 (By similarity). Deubiquitinates RHEB in response to EGF signaling, promoting mTORC1 signaling (By similarity). May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3 (By similarity). This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP (By similarity). May also play a role in the regulation of quality control in the ER (By similarity).[UniProtKB:Q13107]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jy/3jyu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jyu ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of the N-terminal domains of the ubiquitin specific peptidase 4 (USP4)===
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==See Also==
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*[[Thioesterase 3D structures|Thioesterase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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3JYU is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JYU OCA].
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Ubiquitin thiolesterase]]
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[[Category: Arrowsmith CH]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Avvakumov G]]
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[[Category: Avvakumov, G.]]
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[[Category: Bacik JP]]
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[[Category: Bacik, J P.]]
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[[Category: Bochkarev A]]
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[[Category: Bochkarev, A.]]
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[[Category: Dhe-Paganon S]]
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[[Category: Dhe-Paganon, S.]]
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[[Category: Edwards AM]]
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[[Category: Edwards, A M.]]
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[[Category: Walker JR]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Xue S]]
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[[Category: Walker, J R.]]
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[[Category: Xue, S.]]
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[[Category: Hydrolase]]
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[[Category: Protease]]
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[[Category: Proto-oncogene]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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[[Category: Thioesterase]]
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[[Category: Thiol protease]]
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[[Category: Ubiquitin-fold]]
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[[Category: Ubl]]
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[[Category: Ubl conjugation pathway]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 28 14:24:03 2009''
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Current revision

Crystal structure of the N-terminal domains of the ubiquitin specific peptidase 4 (USP4)

PDB ID 3jyu

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