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1d90

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(New page: 200px<br /><applet load="1d90" size="450" color="white" frame="true" align="right" spinBox="true" caption="1d90, resolution 1.700&Aring;" /> '''REFINED CRYSTAL STR...)
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[[Image:1d90.gif|left|200px]]<br /><applet load="1d90" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1d90, resolution 1.700&Aring;" />
 
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'''REFINED CRYSTAL STRUCTURE OF AN OCTANUCLEOTIDE DUPLEX WITH I.T MISMATCHED BASE PAIRS'''<br />
 
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==Overview==
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==REFINED CRYSTAL STRUCTURE OF AN OCTANUCLEOTIDE DUPLEX WITH I.T MISMATCHED BASE PAIRS==
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The structure of the synthetic deoxyoctamer d(GGIGCTCC) has been, determined by single crystal X-ray diffraction techniques to a resolution, of 1.7A. The sequence crystallises in space group P6(1), with unit cell, dimensions a = b = 45.07, c = 45.49A. The refinement converged with a, crystallographic residual R = 0.14 and the location of 81 solvent, molecules. The octamer forms an A-DNA duplex with 6 Watson-Crick (G.C), base pairs and 2 inosine-thymine (I.T) pairs. Refinement of the structure, shows it to be essentially isomorphous with that reported for d(GGGGCTCC), with the mispairs adopting a "wobble" conformation. Conformational, parameters and base stacking interactions are compared to those for the, native duplex d(GGGGCCCC) and other similar sequences. A rationale for the, apparent increased crystal packing efficiency and lattice stability of the, I.T octamer is given.
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<StructureSection load='1d90' size='340' side='right'caption='[[1d90]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1d90]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D90 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D90 FirstGlance]. <br>
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1D90 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1D90 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d90 OCA], [https://pdbe.org/1d90 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d90 RCSB], [https://www.ebi.ac.uk/pdbsum/1d90 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d90 ProSAT]</span></td></tr>
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==Reference==
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</table>
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Refined crystal structure of an octanucleotide duplex with I.T. mismatched base pairs., Cruse WB, Aymani J, Kennard O, Brown T, Jack AG, Leonard GA, Nucleic Acids Res. 1989 Jan 11;17(1):55-72. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=2911488 2911488]
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__TOC__
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[[Category: Protein complex]]
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</StructureSection>
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[[Category: Aymani, J.]]
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[[Category: Large Structures]]
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[[Category: Brown, T.]]
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[[Category: Aymani J]]
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[[Category: Cruse, W.B.T.]]
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[[Category: Brown T]]
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[[Category: Jack, A.G.C.]]
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[[Category: Cruse WBT]]
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[[Category: Kennard, O.]]
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[[Category: Jack AGC]]
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[[Category: Leonard, G.A.]]
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[[Category: Kennard O]]
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[[Category: a-dna]]
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[[Category: Leonard GA]]
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[[Category: double helix]]
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[[Category: mismatched]]
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[[Category: modified]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 02:46:40 2007''
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Current revision

REFINED CRYSTAL STRUCTURE OF AN OCTANUCLEOTIDE DUPLEX WITH I.T MISMATCHED BASE PAIRS

PDB ID 1d90

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