1hmh

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(New page: 200px<br /><applet load="1hmh" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hmh, resolution 2.600&Aring;" /> '''THREE-DIMENSIONAL S...)
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[[Image:1hmh.jpg|left|200px]]<br /><applet load="1hmh" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1hmh, resolution 2.600&Aring;" />
 
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'''THREE-DIMENSIONAL STRUCTURE OF A HAMMERHEAD RIBOZYME'''<br />
 
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==Overview==
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==THREE-DIMENSIONAL STRUCTURE OF A HAMMERHEAD RIBOZYME==
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The hammerhead ribozyme is a small catalytic RNA motif made up of three, base-paired stems and a core of highly conserved, non-complementary, nucleotides essential for catalysis. The X-ray crystallographic structure, of a hammerhead RNA-DNA ribozyme-inhibitor complex at 2.6 A resolution, reveals that the base-paired stems are A-form helices and that the core, has two structural domains. The first domain is formed by the sequence, 5'-CUGA following stem I and is a sharp turn identical to the uridine turn, of transfer RNA, whereas the second is a non-Watson-Crick three-base-pair, duplex with a divalent-ion binding site. The phosphodiester backbone of, the DNA inhibitor strand is splayed out at the phosphate 5' to the, cleavage site. The structure indicates that the ribozyme may destabilize a, substrate strand in order to facilitate twisting of the substrate to allow, cleavage of the scissile bond.
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<StructureSection load='1hmh' size='340' side='right'caption='[[1hmh]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1hmh]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HMH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HMH FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hmh OCA], [https://pdbe.org/1hmh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hmh RCSB], [https://www.ebi.ac.uk/pdbsum/1hmh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hmh ProSAT]</span></td></tr>
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</table>
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==About this Structure==
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==See Also==
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1HMH is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HMH OCA].
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*[[Ribozyme 3D structures|Ribozyme 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Three-dimensional structure of a hammerhead ribozyme., Pley HW, Flaherty KM, McKay DB, Nature. 1994 Nov 3;372(6501):68-74. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7969422 7969422]
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[[Category: Large Structures]]
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[[Category: Protein complex]]
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[[Category: Flaherty KM]]
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[[Category: Flaherty, K.M.]]
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[[Category: McKay DB]]
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[[Category: McKay, D.B.]]
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[[Category: Pley HW]]
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[[Category: Pley, H.W.]]
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[[Category: dna-rna hammerhead ribozyme]]
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[[Category: loop]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 02:47:06 2007''
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THREE-DIMENSIONAL STRUCTURE OF A HAMMERHEAD RIBOZYME

PDB ID 1hmh

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