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1tvt

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(New page: 200px<br /><applet load="1tvt" size="450" color="white" frame="true" align="right" spinBox="true" caption="1tvt" /> '''STRUCTURE OF THE EQUINE INFECTIOUS ANEMIA VI...)
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[[Image:1tvt.jpg|left|200px]]<br /><applet load="1tvt" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1tvt" />
 
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'''STRUCTURE OF THE EQUINE INFECTIOUS ANEMIA VIRUS TAT PROTEIN'''<br />
 
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==Overview==
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==STRUCTURE OF THE EQUINE INFECTIOUS ANEMIA VIRUS TAT PROTEIN==
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Trans-activator (Tat) proteins regulate the transcription of lentiviral, DNA in the host cell genome. These RNA binding proteins participate in the, life cycle of all known lentiviruses, such as the human immunodeficiency, viruses (HIV) or the equine infectious anemia virus (EIAV). The consensus, RNA binding motifs [the trans-activation responsive element (TAR)] of, HIV-1 as well as EIAV Tat proteins are well characterized. The structure, of the 75-amino acid EIAV Tat protein in solution was determined by two-, and three-dimensional nuclear magnetic resonance methods and molecular, dynamics calculations. The protein structure exhibits a well-defined, hydrophobic core of 15 amino acids that serves as a scaffold for two, flexible domains corresponding to the NH2- and COOH-terminal regions. The, core region is a strictly conserved sequence region among the known Tat, proteins. The structural data can be used to explain several of the, observed features of Tat proteins.
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<StructureSection load='1tvt' size='340' side='right'caption='[[1tvt]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1tvt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Equine_infectious_anemia_virus Equine infectious anemia virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TVT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TVT FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tvt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tvt OCA], [https://pdbe.org/1tvt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tvt RCSB], [https://www.ebi.ac.uk/pdbsum/1tvt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tvt ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/O89467_9RETR O89467_9RETR]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tv/1tvt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tvt ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1TVT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Equine_infectious_anemia_virus Equine infectious anemia virus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1TVT OCA].
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*[[Tat protein|Tat protein]]
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__TOC__
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==Reference==
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</StructureSection>
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Structure of the equine infectious anemia virus Tat protein., Willbold D, Rosin-Arbesfeld R, Sticht H, Frank R, Rosch P, Science. 1994 Jun 10;264(5165):1584-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7515512 7515512]
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[[Category: Equine infectious anemia virus]]
[[Category: Equine infectious anemia virus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Roesch, P.]]
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[[Category: Roesch P]]
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[[Category: Willbold, D.]]
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[[Category: Willbold D]]
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[[Category: transcription regulation]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 02:49:56 2007''
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Current revision

STRUCTURE OF THE EQUINE INFECTIOUS ANEMIA VIRUS TAT PROTEIN

PDB ID 1tvt

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