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1hpn

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N.M.R. AND MOLECULAR-MODELLING STUDIES OF THE SOLUTION CONFORMATION OF HEPARIN

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Retrieved from "http://52.214.119.220/wiki/index.php/1hpn"

Categories: Large Structures | Forster MJ | Mulloy B

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-[[Image:1hpn.jpg|left|200px]]<br /><applet load="1hpn" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1hpn" />
-'''N.M.R. AND MOLECULAR-MODELLING STUDIES OF THE SOLUTION CONFORMATION OF HEPARIN'''<br />
-==Overview==
+==N.M.R. AND MOLECULAR-MODELLING STUDIES OF THE SOLUTION CONFORMATION OF HEPARIN==
-The solution conformations of heparin and de-N-sulphated, re-N-acetylated, heparin have been determined by a combination of n.m.r. spectroscopic and, molecular-modelling techniques. The 1H- and 13C-n.m.r. spectra of these, polysaccharides have been assigned. Observed 1H-1H nuclear Overhauser, enhancements (n.O.e.s) have been simulated using the program NOEMOL, [Forster, Jones and Mulloy (1989) J. Mol. Graph. 7, 196-201] for molecular, models derived from conformational-energy calculations; correlation times, for the simulations were chosen to fit experimentally determined 13C, spin-lattice relaxation times. In order to achieve good agreement between, calculated and observed 1H-1H n.O.e.s it was necessary to assume that the, reorientational motion of the polysaccharide molecules was not isotropic, but was that of a symmetric top. The resulting model of heparin in, solution is similar to that determined in the fibrous state by, X-ray-diffraction techniques [Nieduszynski, Gardner and Atkins (1977) Am., Chem. Soc. Symp. Ser. 48, 73-80].
+<StructureSection load='1hpn' size='340' side='right'caption='[[1hpn]]' scene=''>
+== Structural highlights ==
-==About this Structure==
+<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HPN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HPN FirstGlance]. <br>
-HPN is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HPN OCA].
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hpn OCA], [https://pdbe.org/1hpn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hpn RCSB], [https://www.ebi.ac.uk/pdbsum/1hpn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hpn ProSAT]</span></td></tr>
+</table>
-==Reference==
+__TOC__
-N.m.r. and molecular-modelling studies of the solution conformation of heparin., Mulloy B, Forster MJ, Jones C, Davies DB, Biochem J. 1993 Aug 1;293 ( Pt 3):849-58. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8352752 8352752]
+</StructureSection>
-[[Category: Protein complex]]
+[[Category: Large Structures]]
-[[Category: Forster, M.J.]]
+[[Category: Forster MJ]]
-[[Category: Mulloy, B.]]
+[[Category: Mulloy B]]
-[[Category: glycosaminoglycan]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 02:53:35 2007''

1hpn

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N.M.R. AND MOLECULAR-MODELLING STUDIES OF THE SOLUTION CONFORMATION OF HEPARIN

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