1hpn

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /><applet load="1hpn" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hpn" /> '''N.M.R. AND MOLECULAR-MODELLING STUDIES OF TH...)
Current revision (06:30, 1 May 2024) (edit) (undo)
 
(14 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1hpn.jpg|left|200px]]<br /><applet load="1hpn" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1hpn" />
 
-
'''N.M.R. AND MOLECULAR-MODELLING STUDIES OF THE SOLUTION CONFORMATION OF HEPARIN'''<br />
 
-
==Overview==
+
==N.M.R. AND MOLECULAR-MODELLING STUDIES OF THE SOLUTION CONFORMATION OF HEPARIN==
-
The solution conformations of heparin and de-N-sulphated, re-N-acetylated, heparin have been determined by a combination of n.m.r. spectroscopic and, molecular-modelling techniques. The 1H- and 13C-n.m.r. spectra of these, polysaccharides have been assigned. Observed 1H-1H nuclear Overhauser, enhancements (n.O.e.s) have been simulated using the program NOEMOL, [Forster, Jones and Mulloy (1989) J. Mol. Graph. 7, 196-201] for molecular, models derived from conformational-energy calculations; correlation times, for the simulations were chosen to fit experimentally determined 13C, spin-lattice relaxation times. In order to achieve good agreement between, calculated and observed 1H-1H n.O.e.s it was necessary to assume that the, reorientational motion of the polysaccharide molecules was not isotropic, but was that of a symmetric top. The resulting model of heparin in, solution is similar to that determined in the fibrous state by, X-ray-diffraction techniques [Nieduszynski, Gardner and Atkins (1977) Am., Chem. Soc. Symp. Ser. 48, 73-80].
+
<StructureSection load='1hpn' size='340' side='right'caption='[[1hpn]]' scene=''>
-
 
+
== Structural highlights ==
-
==About this Structure==
+
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HPN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HPN FirstGlance]. <br>
-
1HPN is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HPN OCA].
+
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hpn OCA], [https://pdbe.org/1hpn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hpn RCSB], [https://www.ebi.ac.uk/pdbsum/1hpn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hpn ProSAT]</span></td></tr>
-
 
+
</table>
-
==Reference==
+
__TOC__
-
N.m.r. and molecular-modelling studies of the solution conformation of heparin., Mulloy B, Forster MJ, Jones C, Davies DB, Biochem J. 1993 Aug 1;293 ( Pt 3):849-58. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8352752 8352752]
+
</StructureSection>
-
[[Category: Protein complex]]
+
[[Category: Large Structures]]
-
[[Category: Forster, M.J.]]
+
[[Category: Forster MJ]]
-
[[Category: Mulloy, B.]]
+
[[Category: Mulloy B]]
-
[[Category: glycosaminoglycan]]
+
-
 
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 02:53:35 2007''
+

Current revision

N.M.R. AND MOLECULAR-MODELLING STUDIES OF THE SOLUTION CONFORMATION OF HEPARIN

PDB ID 1hpn

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1hpn"
Personal tools