3ikm

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{{Seed}}
 
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[[Image:3ikm.jpg|left|200px]]
 
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==Crystal structure of human mitochondrial DNA polymerase holoenzyme==
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The line below this paragraph, containing "STRUCTURE_3ikm", creates the "Structure Box" on the page.
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<StructureSection load='3ikm' size='340' side='right'caption='[[3ikm]], [[Resolution|resolution]] 3.24&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ikm]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IKM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IKM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.24&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ikm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ikm OCA], [https://pdbe.org/3ikm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ikm RCSB], [https://www.ebi.ac.uk/pdbsum/3ikm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ikm ProSAT]</span></td></tr>
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{{STRUCTURE_3ikm| PDB=3ikm | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/DPOG2_HUMAN DPOG2_HUMAN] Defects in POLG2 are the cause of progressive external ophthalmoplegia with mitochondrial DNA deletions autosomal dominant type 4 (PEOA4) [MIM:[https://omim.org/entry/610131 610131]. Progressive external ophthalmoplegia is characterized by progressive weakness of ocular muscles and levator muscle of the upper eyelid. In a minority of cases, it is associated with skeletal myopathy, which predominantly involves axial or proximal muscles and which causes abnormal fatigability and even permanent muscle weakness. Ragged-red fibers and atrophy are found on muscle biopsy. A large proportion of chronic ophthalmoplegias are associated with other symptoms, leading to a multisystemic pattern of this disease. Additional symptoms are variable, and may include cataracts, hearing loss, sensory axonal neuropathy, ataxia, depression, hypogonadism, and parkinsonism.<ref>PMID:16685652</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/DPOG2_HUMAN DPOG2_HUMAN] Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. Binds to ss-DNA.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ik/3ikm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ikm ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of human mitochondrial DNA polymerase holoenzyme===
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==See Also==
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*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_19837034}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 19837034 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_19837034}}
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==About this Structure==
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3IKM is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IKM OCA].
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==Reference==
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<ref group="xtra">PMID:19837034</ref><references group="xtra"/>
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[[Category: DNA-directed DNA polymerase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Kennedy, W D.]]
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[[Category: Large Structures]]
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[[Category: Lee, Y-S.]]
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[[Category: Kennedy WD]]
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[[Category: Yin, Y W.]]
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[[Category: Lee Y-S]]
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[[Category: Disease mutation]]
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[[Category: Yin YW]]
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[[Category: Dna replication]]
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[[Category: Dna-binding]]
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[[Category: Dna-directed dna polymerase]]
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[[Category: Human mitochondrial dna polymerase]]
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[[Category: Magnesium]]
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[[Category: Mitochondrion]]
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[[Category: Neuropathy]]
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[[Category: Nucleotidyltransferase]]
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[[Category: Polymorphism]]
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[[Category: Progressive external ophthalmoplegia]]
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[[Category: Transferase]]
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[[Category: Transit peptide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 4 11:00:03 2009''
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Current revision

Crystal structure of human mitochondrial DNA polymerase holoenzyme

PDB ID 3ikm

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