3jzi

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{{Seed}}
 
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[[Image:3jzi.jpg|left|200px]]
 
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==Crystal structure of biotin carboxylase from E. Coli in complex with benzimidazole series==
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The line below this paragraph, containing "STRUCTURE_3jzi", creates the "Structure Box" on the page.
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<StructureSection load='3jzi' size='340' side='right'caption='[[3jzi]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3jzi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JZI FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.31&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JZL:7-AMINO-2-[(2-CHLOROBENZYL)AMINO]-1-{[(1S,2S)-2-HYDROXYCYCLOHEPTYL]METHYL}-1H-BENZIMIDAZOLE-5-CARBOXAMIDE'>JZL</scene></td></tr>
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{{STRUCTURE_3jzi| PDB=3jzi | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jzi OCA], [https://pdbe.org/3jzi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jzi RCSB], [https://www.ebi.ac.uk/pdbsum/3jzi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jzi ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ACCC_ECOLI ACCC_ECOLI] This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jz/3jzi_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jzi ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The biotin carboxylase (AccC) is part of the multi-component bacterial acetyl coenzyme-A carboxylase (ACCase) and is essential for pathogen survival. We describe herein the affinity optimization of an initial hit to give 2-(2-chlorobenzylamino)-1-(cyclohexylmethyl)-1H-benzo[d]imidazole-5-carbox amide (1), which was identified using our proprietary Automated Ligand Identification System (ALIS).(1) The X-ray co-crystal structure of 1 was solved and revealed several key interactions and opportunities for further optimization in the ATP site of AccC. Structure Based Drug Design (SBDD) and parallel synthetic approaches resulted in a novel series of AccC inhibitors, exemplified by (R)-2-(2-chlorobenzylamino)-1-(2,3-dihydro-1H-inden-1-yl)-1H-imidazo[4,5-b ]pyridine-5-carboxamide (40). This compound is a potent and selective inhibitor of bacterial AccC with an IC(50) of 20 nM and a MIC of 0.8 microg/mL against a sensitized strain of Escherichia coli (HS294 E. coli).
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===Crystal structure of biotin carboxylase from E. Coli in complex with benzimidazole series===
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Discovery and optimization of antibacterial AccC inhibitors.,Cheng CC, Shipps GW Jr, Yang Z, Sun B, Kawahata N, Soucy KA, Soriano A, Orth P, Xiao L, Mann P, Black T Bioorg Med Chem Lett. 2009 Dec 1;19(23):6507-14. Epub 2009 Oct 28. PMID:19875284<ref>PMID:19875284</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3jzi" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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3JZI is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZI OCA].
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*[[Acetyl-CoA carboxylase 3D structures|Acetyl-CoA carboxylase 3D structures]]
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[[Category: Escherichia coli]]
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== References ==
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[[Category: Black, T.]]
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<references/>
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[[Category: Cheng, C.]]
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__TOC__
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[[Category: Kawahata, N.]]
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</StructureSection>
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[[Category: Mann, P.]]
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[[Category: Escherichia coli K-12]]
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[[Category: Orth, P.]]
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[[Category: Large Structures]]
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[[Category: Shipps, G W.]]
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[[Category: Black T]]
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[[Category: Soriano, A.]]
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[[Category: Cheng C]]
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[[Category: Soucy, K.]]
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[[Category: Kawahata N]]
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[[Category: Sun, B.]]
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[[Category: Mann P]]
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[[Category: Xiao, L.]]
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[[Category: Orth P]]
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[[Category: Yang, Z.]]
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[[Category: Shipps GW]]
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[[Category: Accase]]
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[[Category: Soriano A]]
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[[Category: Accc]]
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[[Category: Soucy K]]
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[[Category: Acetyl coenzyme-a carboxylase]]
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[[Category: Sun B]]
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[[Category: Atp-binding]]
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[[Category: Xiao L]]
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[[Category: Biotin]]
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[[Category: Yang Z]]
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[[Category: Biotin carboxylase]]
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[[Category: Fatty acid biosynthesis]]
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[[Category: Ligase]]
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[[Category: Lipid synthesis]]
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[[Category: Nucleotide-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 4 11:02:41 2009''
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Current revision

Crystal structure of biotin carboxylase from E. Coli in complex with benzimidazole series

PDB ID 3jzi

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