1dcw

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(New page: 200px<br /><applet load="1dcw" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dcw, resolution 2.10&Aring;" /> '''STRUCTURE OF A FOUR-...)
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[[Image:1dcw.gif|left|200px]]<br /><applet load="1dcw" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1dcw, resolution 2.10&Aring;" />
 
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'''STRUCTURE OF A FOUR-WAY JUNCTION IN AN INVERTED REPEAT SEQUENCE.'''<br />
 
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==Overview==
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==STRUCTURE OF A FOUR-WAY JUNCTION IN AN INVERTED REPEAT SEQUENCE.==
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Holliday junctions are important structural intermediates in, recombination, viral integration, and DNA repair. We present here the, single-crystal structure of the inverted repeat sequence d(CCGGTACCGG) as, a Holliday junction at the nominal resolution of 2. 1 A. Unlike the, previous crystal structures, this DNA junction has B-DNA arms with all, standard Watson-Crick base pairs; it therefore represents the intermediate, proposed by Holliday as being involved in homologous recombination. The, junction is in the stacked-X conformation, with two interconnected, duplexes formed by coaxially stacked arms, and is crossed at an angle of, 41.4 degrees as a right-handed X. A sequence comparison with previous, B-DNA and junction crystal structures shows that an ACC trinucleotide, forms the core of a stable junction in this system. The 3'-C x G base pair, of this ACC core forms direct and water-mediated hydrogen bonds to the, phosphates at the crossover strands. Interactions within this core define, the conformation of the Holliday junction, including the angle relating, the stacked duplexes and how the base pairs are stacked in the stable form, of the junction.
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<StructureSection load='1dcw' size='340' side='right'caption='[[1dcw]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1dcw]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DCW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DCW FirstGlance]. <br>
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1DCW is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with NA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DCW OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dcw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dcw OCA], [https://pdbe.org/1dcw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dcw RCSB], [https://www.ebi.ac.uk/pdbsum/1dcw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dcw ProSAT]</span></td></tr>
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The Holliday junction in an inverted repeat DNA sequence: sequence effects on the structure of four-way junctions., Eichman BF, Vargason JM, Mooers BH, Ho PS, Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):3971-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10760268 10760268]
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</table>
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[[Category: Protein complex]]
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__TOC__
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[[Category: Eichman, B.F.]]
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</StructureSection>
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[[Category: Ho, P.S.]]
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[[Category: Large Structures]]
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[[Category: Mooers, B.H.M.]]
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[[Category: Eichman BF]]
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[[Category: Vargason, J.M.]]
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[[Category: Ho PS]]
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[[Category: NA]]
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[[Category: Mooers BHM]]
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[[Category: deoxyribonucleic acid]]
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[[Category: Vargason JM]]
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[[Category: four-way junction]]
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[[Category: holliday junction]]
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[[Category: inverted repeat]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 02:59:17 2007''
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STRUCTURE OF A FOUR-WAY JUNCTION IN AN INVERTED REPEAT SEQUENCE.

PDB ID 1dcw

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