1u09

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(New page: 200px<br /><applet load="1u09" size="450" color="white" frame="true" align="right" spinBox="true" caption="1u09, resolution 1.91&Aring;" /> '''Footand Mouth Diseas...)
Current revision (13:30, 13 March 2024) (edit) (undo)
 
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[[Image:1u09.gif|left|200px]]<br /><applet load="1u09" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1u09, resolution 1.91&Aring;" />
 
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'''Footand Mouth Disease Virus RNA-dependent RNA polymerase'''<br />
 
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==Overview==
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==Footand Mouth Disease Virus RNA-dependent RNA polymerase==
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Genome replication in picornaviruses is catalyzed by a virally encoded, RNA-dependent RNA polymerase, termed 3D. The enzyme performs this, operation, together with other viral and probably host proteins, in the, cytoplasm of their host cells. The crystal structure of the 3D polymerase, of foot-and-mouth disease virus, one of the most important animal, pathogens, has been determined unliganded and bound to a template-primer, RNA decanucleotide. The enzyme folds in the characteristic fingers, palm, and thumb subdomains, with the presence of an NH2-terminal segment that, encircles the active site. In the complex, several conserved amino acid, side chains bind to the template-primer, likely mediating the initiation, of RNA synthesis. The structure provides essential information for studies, on RNA replication and the design of antiviral compounds.
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<StructureSection load='1u09' size='340' side='right'caption='[[1u09]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1u09]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Foot-and-mouth_disease_virus_C-S8c1 Foot-and-mouth disease virus C-S8c1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U09 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U09 FirstGlance]. <br>
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1U09 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Foot-and-mouth_disease_virus Foot-and-mouth disease virus]. Active as [http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1U09 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.91&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u09 OCA], [https://pdbe.org/1u09 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u09 RCSB], [https://www.ebi.ac.uk/pdbsum/1u09 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u09 ProSAT]</span></td></tr>
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==Reference==
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</table>
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Structure of foot-and-mouth disease virus RNA-dependent RNA polymerase and its complex with a template-primer RNA., Ferrer-Orta C, Arias A, Perez-Luque R, Escarmis C, Domingo E, Verdaguer N, J Biol Chem. 2004 Nov 5;279(45):47212-21. Epub 2004 Aug 3. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15294895 15294895]
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== Function ==
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[[Category: Foot-and-mouth disease virus]]
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[https://www.uniprot.org/uniprot/Q9QCE4_9PICO Q9QCE4_9PICO] Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266] RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS000199_004_010047]
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[[Category: Protein complex]]
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== Evolutionary Conservation ==
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[[Category: RNA-directed RNA polymerase]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Arias, A.]]
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Check<jmol>
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[[Category: Domingo, E.]]
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<jmolCheckbox>
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[[Category: Escarmis, C.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u0/1u09_consurf.spt"</scriptWhenChecked>
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[[Category: Ferrer-Orta, C.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Perez-Luque, R.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Verdaguer, N.]]
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</jmolCheckbox>
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[[Category: foot and mouth disease virus]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u09 ConSurf].
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[[Category: protein-dna complex]]
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<div style="clear:both"></div>
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[[Category: rna-dependent rna polymerase]]
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__TOC__
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</StructureSection>
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 03:04:32 2007''
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[[Category: Foot-and-mouth disease virus C-S8c1]]
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[[Category: Large Structures]]
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[[Category: Arias A]]
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[[Category: Domingo E]]
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[[Category: Escarmis C]]
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[[Category: Ferrer-Orta C]]
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[[Category: Perez-Luque R]]
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[[Category: Verdaguer N]]

Current revision

Footand Mouth Disease Virus RNA-dependent RNA polymerase

PDB ID 1u09

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