3ivc

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{{Seed}}
 
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[[Image:3ivc.png|left|200px]]
 
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==Crystal structure of pantothenate synthetase in complex with 2-(2-((benzofuran-2-ylmethoxy)carbonyl)-5-methoxy-1H-indol-1-yl)acetic acid==
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The line below this paragraph, containing "STRUCTURE_3ivc", creates the "Structure Box" on the page.
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<StructureSection load='3ivc' size='340' side='right'caption='[[3ivc]], [[Resolution|resolution]] 2.13&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ivc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IVC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IVC FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.13&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EOH:ETHANOL'>EOH</scene>, <scene name='pdbligand=FG4:{2-[(1-BENZOFURAN-2-YLMETHOXY)CARBONYL]-5-METHOXY-1H-INDOL-1-YL}ACETIC+ACID'>FG4</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3ivc| PDB=3ivc | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ivc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ivc OCA], [https://pdbe.org/3ivc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ivc RCSB], [https://www.ebi.ac.uk/pdbsum/3ivc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ivc ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PANC_MYCTU PANC_MYCTU] Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.<ref>PMID:11669627</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iv/3ivc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ivc ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of pantothenate synthetase in complex with 2-(2-((benzofuran-2-ylmethoxy)carbonyl)-5-methoxy-1H-indol-1-yl)acetic acid===
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==See Also==
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*[[Pantothenate synthetase|Pantothenate synthetase]]
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== References ==
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==About this Structure==
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<references/>
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3IVC is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IVC OCA].
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__TOC__
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</StructureSection>
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==Reference==
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[[Category: Large Structures]]
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<ref group="xtra">PMID:19780086</ref><references group="xtra"/>
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[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Pantoate--beta-alanine ligase]]
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[[Category: Abell C]]
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[[Category: Abell, C.]]
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[[Category: Blundell TL]]
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[[Category: Blundell, T L.]]
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[[Category: Ciulli A]]
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[[Category: Ciulli, A.]]
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[[Category: Hung AW]]
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[[Category: Hung, A W.]]
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[[Category: Silvestre HL]]
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[[Category: Silvestre, H L.]]
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[[Category: Wen S]]
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[[Category: Wen, S.]]
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[[Category: Atp-binding]]
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[[Category: Cytoplasm]]
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[[Category: Fragment-based lead discovery]]
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[[Category: Ligase]]
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[[Category: Magnesium]]
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[[Category: Metal-binding]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Nucleotide-binding]]
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[[Category: Pantothenate biosynthesis]]
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[[Category: Pantothenate synthetase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 11 20:05:06 2009''
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Current revision

Crystal structure of pantothenate synthetase in complex with 2-(2-((benzofuran-2-ylmethoxy)carbonyl)-5-methoxy-1H-indol-1-yl)acetic acid

PDB ID 3ivc

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OCA

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