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2zxc

From Proteopedia

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{{Seed}}
 
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[[Image:2zxc.png|left|200px]]
 
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<!--
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==Ceramidase complexed with C2==
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The line below this paragraph, containing "STRUCTURE_2zxc", creates the "Structure Box" on the page.
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<StructureSection load='2zxc' size='340' side='right'caption='[[2zxc]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2zxc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZXC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZXC FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2ED:N-[(1R,2R,3E)-2-HYDROXY-1-(HYDROXYMETHYL)HEPTADEC-3-EN-1-YL]ACETAMIDE'>2ED</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_2zxc| PDB=2zxc | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zxc OCA], [https://pdbe.org/2zxc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zxc RCSB], [https://www.ebi.ac.uk/pdbsum/2zxc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zxc ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NCASE_PSEAE NCASE_PSEAE] Catalyzes the cleavage of the N-acyl linkage of the ceramides (Cers) to yield sphingosine (Sph) and free fatty acid at an optimal pH of 8-9. Also catalyzes the synthesis of Cers from Sph and fatty acid.<ref>PMID:9603946</ref> <ref>PMID:19088069</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zx/2zxc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zxc ConSurf].
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<div style="clear:both"></div>
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===seramidase complexed with C2===
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==See Also==
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*[[Ceramidase|Ceramidase]]
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*[[Ceramidase 3D PDB structures|Ceramidase 3D PDB structures]]
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== References ==
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The line below this paragraph, {{ABSTRACT_PUBMED_19088069}}, adds the Publication Abstract to the page
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<references/>
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(as it appears on PubMed at http://www.pubmed.gov), where 19088069 is the PubMed ID number.
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__TOC__
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</StructureSection>
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{{ABSTRACT_PUBMED_19088069}}
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[[Category: Large Structures]]
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==About this Structure==
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2ZXC is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZXC OCA].
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==Reference==
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<ref group="xtra">PMID:19088069</ref><references group="xtra"/>
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[[Category: Ceramidase]]
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[[Category: Pseudomonas aeruginosa]]
[[Category: Pseudomonas aeruginosa]]
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[[Category: Inoue, T.]]
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[[Category: Inoue T]]
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[[Category: Ito, M.]]
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[[Category: Ito M]]
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[[Category: Kakuta, Y.]]
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[[Category: Kakuta Y]]
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[[Category: Matsumura, H.]]
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[[Category: Matsumura H]]
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[[Category: Okano, H.]]
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[[Category: Okano H]]
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[[Category: Okino, N.]]
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[[Category: Okino N]]
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[[Category: Beta-prism fold surrounded by six alpha helix]]
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[[Category: Hydrolase]]
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[[Category: Lipid metabolism]]
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[[Category: Secreted]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 11 20:07:41 2009''
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Current revision

Ceramidase complexed with C2

PDB ID 2zxc

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