3hw1

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:15, 30 October 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:3hw1.png|left|200px]]
 
-
<!--
+
==Structure of Bace (beta secretase) in complex with ligand EV2==
-
The line below this paragraph, containing "STRUCTURE_3hw1", creates the "Structure Box" on the page.
+
<StructureSection load='3hw1' size='340' side='right'caption='[[3hw1]], [[Resolution|resolution]] 2.48&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3hw1]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HW1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HW1 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.48&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EV2:3-PYRROLIDIN-1-YLQUINOXALIN-2-AMINE'>EV2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-
{{STRUCTURE_3hw1| PDB=3hw1 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hw1 OCA], [https://pdbe.org/3hw1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hw1 RCSB], [https://www.ebi.ac.uk/pdbsum/3hw1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hw1 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hw/3hw1_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hw1 ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Novel nonpeptidic inhibitors of beta-secretase (BACE1) have been discovered by employing a fragment-based biochemical screening approach. A diverse library of 20000 low-molecular weight compounds were screened and yielded 26 novel hits that were confirmed by biochemical and surface plasmon resonance secondary assays. We describe here fragment inhibitors cocrystallized with BACE1 in a flap open and flap closed conformation as determined by X-ray crystallography.
-
===Structure of Bace (beta secretase) in complex with ligand EV2===
+
Fragment-Based Discovery of BACE1 Inhibitors Using Functional Assays.,Godemann R, Madden J, Kramer J, Smith M, Fritz U, Hesterkamp T, Barker J, Hoppner S, Hallett D, Cesura A, Ebneth A, Kemp J Biochemistry. 2009 Oct 23. PMID:19799414<ref>PMID:19799414</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 3hw1" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_19799414}}, adds the Publication Abstract to the page
+
*[[Beta secretase 3D structures|Beta secretase 3D structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 19799414 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_19799414}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
3HW1 is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HW1 OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:19799414</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Memapsin 2]]
+
[[Category: Large Structures]]
-
[[Category: Barker, J.]]
+
[[Category: Barker J]]
-
[[Category: Ebneth, A.]]
+
[[Category: Ebneth A]]
-
[[Category: Godemann, R.]]
+
[[Category: Godemann R]]
-
[[Category: Kramer, J.]]
+
[[Category: Kramer J]]
-
[[Category: Madden, J.]]
+
[[Category: Madden J]]
-
[[Category: Smith, M A.]]
+
[[Category: Smith MA]]
-
[[Category: Alternative splicing]]
+
-
[[Category: Alzheimer's disease]]
+
-
[[Category: Amyloid precursor protein secretase]]
+
-
[[Category: Aspartic endopeptidase]]
+
-
[[Category: Aspartic protease]]
+
-
[[Category: Aspartyl protease]]
+
-
[[Category: Base]]
+
-
[[Category: Beta-secretase]]
+
-
[[Category: Disulfide bond]]
+
-
[[Category: Fluorescence polarisation]]
+
-
[[Category: Fragment-based drug design]]
+
-
[[Category: Glycoprotein]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Memapsin 2]]
+
-
[[Category: Polymorphism]]
+
-
[[Category: Protease]]
+
-
[[Category: Transmembrane]]
+
-
[[Category: Zymogen]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 11 20:08:23 2009''
+

Current revision

Structure of Bace (beta secretase) in complex with ligand EV2

PDB ID 3hw1

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3hw1"
Personal tools