2kix

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:33, 19 July 2023) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2kix.jpg|left|200px]]
 
-
<!--
+
==Channel domain of BM2 protein from influenza B virus==
-
The line below this paragraph, containing "STRUCTURE_2kix", creates the "Structure Box" on the page.
+
<StructureSection load='2kix' size='340' side='right'caption='[[2kix]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2kix]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_B_virus_(B/Taiwan/70061/2006) Influenza B virus (B/Taiwan/70061/2006)]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KIX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KIX FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kix OCA], [https://pdbe.org/2kix PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kix RCSB], [https://www.ebi.ac.uk/pdbsum/2kix PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kix ProSAT]</span></td></tr>
-
{{STRUCTURE_2kix| PDB=2kix | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/B4UQM4_9INFB B4UQM4_9INFB]
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Influenza B virus contains an integral membrane protein, BM2, that oligomerizes in the viral membrane to form a pH-activated proton channel. Here we report the solution structures of both the membrane-embedded channel domain and the cytoplasmic domain of BM2. The channel domain assumes a left-handed coiled-coil tetramer formation with a helical packing angle of -37 degrees to form a polar pore in the membrane for conducting ions. Mutagenesis and proton flux experiments identified residues involved in proton relay and suggest a mechanism of proton conductance. The cytoplasmic domain of BM2 also forms a coiled-coil tetramer. It has a bipolar charge distribution, in which a negatively charged region interacts specifically with the M1 matrix protein that is involved in packaging the genome in the virion. This interaction suggests BM2 also recruits matrix proteins to the cell surface during virus budding, making BM2 an unusual membrane protein with the dual roles of conducting ions and recruiting proteins to the membrane.
-
===Channel domain of BM2 protein from influenza B virus===
+
Solution structure and functional analysis of the influenza B proton channel.,Wang J, Pielak RM, McClintock MA, Chou JJ Nat Struct Mol Biol. 2009 Dec;16(12):1267-71. Epub 2009 Nov 8. PMID:19898475<ref>PMID:19898475</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 2kix" style="background-color:#fffaf0;"></div>
-
==About this Structure==
+
==See Also==
-
2KIX is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KIX OCA].
+
*[[M2 protein|M2 protein]]
-
[[Category: Viruses]]
+
== References ==
-
[[Category: Chou, J.]]
+
<references/>
-
[[Category: McClintock, M.]]
+
__TOC__
-
[[Category: Pielak, R.]]
+
</StructureSection>
-
[[Category: Wang, J.]]
+
[[Category: Large Structures]]
-
[[Category: Bm2]]
+
[[Category: Chou J]]
-
[[Category: Channel]]
+
[[Category: McClintock M]]
-
[[Category: Influenza b]]
+
[[Category: Pielak R]]
-
[[Category: Transport protein]]
+
[[Category: Wang J]]
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 11 22:10:27 2009''
+

Current revision

Channel domain of BM2 protein from influenza B virus

PDB ID 2kix

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2kix"
Personal tools