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2knp

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{{Seed}}
 
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[[Image:2knp.jpg|left|200px]]
 
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==Isolation and characterization of peptides from Momordica cochinchinensis seeds.==
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The line below this paragraph, containing "STRUCTURE_2knp", creates the "Structure Box" on the page.
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<StructureSection load='2knp' size='340' side='right'caption='[[2knp]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2knp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Momordica_cochinchinensis Momordica cochinchinensis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KNP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KNP FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2knp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2knp OCA], [https://pdbe.org/2knp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2knp RCSB], [https://www.ebi.ac.uk/pdbsum/2knp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2knp ProSAT]</span></td></tr>
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{{STRUCTURE_2knp| PDB=2knp | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/D0VWX1_MOMCO D0VWX1_MOMCO]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The plant Momordica cochinchinensis has traditionally been used in Chinese medicine to treat a variety of illnesses. A range of bioactive molecules have been isolated from this plant, including peptides, which are the focus of this study. Here we report the isolation and characterization of two novel peptides, MCoCC-1 and MCoCC-2, containing 33 and 32 amino acids, respectively, which are toxic against three cancer cell lines. The two peptides are highly homologous to one another, but show no sequence similarity to known peptides. Elucidation of the three-dimensional structure of MCoCC-1 suggests the presence of a cystine knot motif, also found in a family of trypsin inhibitor peptides from this plant. However, unlike its structural counterparts, MCoCC-1 does not inhibit trypsin. MCoCC-1 has a well-defined structure, characterized mainly by a triple-stranded antiparallel beta-sheet, but unlike the majority of cystine knot proteins MCoCC-1 contains a disordered loop presumably as a result of flexibility in a localized region of the molecule. Of the cell lines tested, MCoCC-1 is the most toxic against a human melanoma cell line (MM96L) and is nonhemolytic to human erythrocytes. The role of these peptides within the plant remains to be determined.
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===Isolation and characterization of peptides from Momordica cochinchinensis seeds.===
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Isolation and characterization of peptides from Momordica cochinchinensis seeds.,Chan LY, Wang CK, Major JM, Greenwood KP, Lewis RJ, Craik DJ, Daly NL J Nat Prod. 2009 Aug;72(8):1453-8. PMID:19711988<ref>PMID:19711988</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19711988}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2knp" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19711988 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19711988}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2KNP is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Momordica_cochinchinensis Momordica cochinchinensis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KNP OCA].
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==Reference==
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<ref group="xtra">PMID:19711988</ref><references group="xtra"/>
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[[Category: Momordica cochinchinensis]]
[[Category: Momordica cochinchinensis]]
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[[Category: Chan, L.]]
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[[Category: Chan L]]
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[[Category: Daly, N L.]]
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[[Category: Daly NL]]
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[[Category: Cystine knot motif]]
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[[Category: Cytotoxic]]
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[[Category: Disulfide-rich peptide]]
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[[Category: Mcocc-1]]
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[[Category: Mcocc-2]]
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[[Category: Melanoma cell line]]
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[[Category: Momordica cochinchinensis]]
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[[Category: Non-hemolytic]]
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[[Category: Seeds extract]]
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[[Category: Unknown function]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 11 22:12:37 2009''
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Current revision

Isolation and characterization of peptides from Momordica cochinchinensis seeds.

PDB ID 2knp

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