3gnf

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{{Seed}}
 
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[[Image:3gnf.jpg|left|200px]]
 
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==P1 Crystal structure of the N-terminal R1-R7 of murine MVP==
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The line below this paragraph, containing "STRUCTURE_3gnf", creates the "Structure Box" on the page.
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<StructureSection load='3gnf' size='340' side='right'caption='[[3gnf]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3gnf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GNF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GNF FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gnf OCA], [https://pdbe.org/3gnf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gnf RCSB], [https://www.ebi.ac.uk/pdbsum/3gnf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gnf ProSAT]</span></td></tr>
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{{STRUCTURE_3gnf| PDB=3gnf | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MVP_MOUSE MVP_MOUSE] Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gn/3gnf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gnf ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Vaults are ubiquitous ribonucleoprotein complexes involved in a diversity of cellular processes, including multidrug resistance, transport mechanisms and signal transmission. The vault particle shows a barrel-shaped structure organized in two identical moieties, each consisting of 39 copies of the major vault protein MVP. Earlier data indicated that vault halves can dissociate at acidic pH. The crystal structure of the vault particle solved at 8 A resolution, together with the 2.1-A structure of the seven N-terminal domains (R1-R7) of MVP, reveal the interactions governing vault association and provide an explanation for a reversible dissociation induced by low pH. The structural comparison with the recently published 3.5 A model shows major discrepancies, both in the main chain tracing and in the side chain assignment of the two terminal domains R1 and R2.
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===P1 Crystal structure of the N-terminal R1-R7 of murine MVP===
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The mechanism of vault opening from the high resolution structure of the N-terminal repeats of MVP.,Querol-Audi J, Casanas A, Uson I, Luque D, Caston JR, Fita I, Verdaguer N EMBO J. 2009 Nov 4;28(21):3450-7. Epub 2009 Sep 24. PMID:19779459<ref>PMID:19779459</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19779459}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3gnf" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19779459 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19779459}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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3GNF is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GNF OCA].
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==Reference==
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<ref group="xtra">PMID:19779459</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Casanas, A.]]
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[[Category: Casanas A]]
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[[Category: Caston, J R.]]
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[[Category: Caston JR]]
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[[Category: Fita, I.]]
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[[Category: Fita I]]
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[[Category: Luque, D.]]
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[[Category: Luque D]]
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[[Category: Querol-Audi, J.]]
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[[Category: Querol-Audi J]]
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[[Category: Uson, I.]]
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[[Category: Uson I]]
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[[Category: Verdaguer, N.]]
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[[Category: Verdaguer N]]
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[[Category: Acetylation]]
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[[Category: Beta sheet]]
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[[Category: Cytoplasm]]
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[[Category: Phosphoprotein]]
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[[Category: Ribonucleoprotein]]
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[[Category: Structural protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 11 22:23:48 2009''
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Current revision

P1 Crystal structure of the N-terminal R1-R7 of murine MVP

PDB ID 3gnf

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