3iqs

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{{Seed}}
 
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[[Image:3iqs.jpg|left|200px]]
 
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==Crystal structure of the anti-viral APOBEC3G catalytic domain==
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The line below this paragraph, containing "STRUCTURE_3iqs", creates the "Structure Box" on the page.
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<StructureSection load='3iqs' size='340' side='right'caption='[[3iqs]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3iqs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IQS FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3iqs| PDB=3iqs | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iqs OCA], [https://pdbe.org/3iqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iqs RCSB], [https://www.ebi.ac.uk/pdbsum/3iqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iqs ProSAT]</span></td></tr>
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</table>
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===Crystal structure of the anti-viral APOBEC3G catalytic domain===
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== Function ==
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[https://www.uniprot.org/uniprot/ABC3G_HUMAN ABC3G_HUMAN] DNA deaminase (cytidine deaminase) that mediates a form of innate resistance to retroviral infections (at least to HIV-1 infection) by triggering G-to-A hypermutation in the newly synthesized viral DNA. The replacements C-to-U in the minus strand DNA of HIV-1 during reverse transcription, leads to G-to-A transitions in the plus strand. The inhibition of viral replication is either due to the degradation of the minus strand before its integration or to the lethality of the hypermutations. Modification of both DNA strands is not excluded. This antiviral activity is neutralized by the virion infectivity factor (VIF), that prevents the incorporation of APOBEC3G into progeny HIV-1 virions by both inhibiting its translation and/or by inducing its ubiquitination and subsequent degradation by the 26S proteasome. May also prevent the transposition of a subset of retroelements. Binds a variety of RNAs, but does not display detectable APOB, NF1 and NAT1 mRNA editing.<ref>PMID:14557625</ref> <ref>PMID:12167863</ref> <ref>PMID:12808466</ref> <ref>PMID:12809610</ref> <ref>PMID:12808465</ref> <ref>PMID:12859895</ref> <ref>PMID:12970355</ref> <ref>PMID:14528300</ref> <ref>PMID:15031497</ref> <ref>PMID:16527742</ref> <ref>PMID:21123384</ref> <ref>PMID:18288108</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_18849968}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 18849968 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iq/3iqs_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_18849968}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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3IQS is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IQS OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3iqs ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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<ref group="xtra">PMID:18849968</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bransteitter, R.]]
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[[Category: Large Structures]]
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[[Category: Chang, Y P.]]
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[[Category: Bransteitter R]]
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[[Category: Chelico, L.]]
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[[Category: Chang YP]]
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[[Category: Chen, X S.]]
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[[Category: Chelico L]]
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[[Category: Goodman, R F.]]
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[[Category: Chen XS]]
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[[Category: Holden, L G.]]
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[[Category: Goodman RF]]
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[[Category: Prochnow, C.]]
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[[Category: Holden LG]]
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[[Category: Sen, U.]]
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[[Category: Prochnow C]]
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[[Category: Stevens, R C.]]
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[[Category: Sen U]]
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[[Category: Alternative splicing]]
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[[Category: Stevens RC]]
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[[Category: Antiviral defense]]
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[[Category: Cytoplasm]]
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[[Category: Five beta-strands surrounded by six alpha-helice]]
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[[Category: Host-virus interaction]]
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[[Category: Hydrolase]]
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[[Category: Metal-binding]]
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[[Category: Nucleus]]
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[[Category: Polymorphism]]
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[[Category: Ubl conjugation]]
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[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 11 22:31:16 2009''
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Current revision

Crystal structure of the anti-viral APOBEC3G catalytic domain

PDB ID 3iqs

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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