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3iwn

From Proteopedia

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{{Seed}}
 
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[[Image:3iwn.jpg|left|200px]]
 
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==Co-crystal structure of a bacterial c-di-GMP riboswitch==
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The line below this paragraph, containing "STRUCTURE_3iwn", creates the "Structure Box" on the page.
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<StructureSection load='3iwn' size='340' side='right'caption='[[3iwn]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3iwn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. The October 2010 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Riboswitches'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2010_10 10.2210/rcsb_pdb/mom_2010_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IWN FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C2E:9,9-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d 3,2-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)'>C2E</scene></td></tr>
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{{STRUCTURE_3iwn| PDB=3iwn | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iwn OCA], [https://pdbe.org/3iwn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iwn RCSB], [https://www.ebi.ac.uk/pdbsum/3iwn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iwn ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SNRPA_HUMAN SNRPA_HUMAN] Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro.<ref>PMID:9848648</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iw/3iwn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3iwn ConSurf].
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<div style="clear:both"></div>
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===Co-crystal structure of a bacterial c-di-GMP riboswitch===
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==See Also==
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*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
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*[[Riboswitch 3D structures|Riboswitch 3D structures]]
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==About this Structure==
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== References ==
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3IWN is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWN OCA].
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Amare, A R.Ferre-D.]]
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[[Category: Large Structures]]
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[[Category: Baird, N J.]]
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[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Kulshina, N.]]
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[[Category: Riboswitches]]
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[[Category: Acetylation]]
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[[Category: Vibrio cholerae]]
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[[Category: Mrna processing]]
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[[Category: Baird NJ]]
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[[Category: Mrna splicing]]
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[[Category: Ferre-D'Amare AR]]
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[[Category: Nucleus]]
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[[Category: Kulshina N]]
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[[Category: Phosphoprotein]]
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[[Category: Ribonucleoprotein]]
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[[Category: Riboswitch]]
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[[Category: Rna]]
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[[Category: Rna-binding]]
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[[Category: Rna/rna binding protein complex]]
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[[Category: Spliceosome]]
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[[Category: U1a]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 11 22:32:26 2009''
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Current revision

Co-crystal structure of a bacterial c-di-GMP riboswitch

PDB ID 3iwn

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