2bfu

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{{Seed}}
 
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[[Image:2bfu.png|left|200px]]
 
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==X-ray structure of CPMV top component==
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The line below this paragraph, containing "STRUCTURE_2bfu", creates the "Structure Box" on the page.
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<StructureSection load='2bfu' size='340' side='right'caption='[[2bfu]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2bfu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cowpea_mosaic_virus Cowpea mosaic virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BFU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BFU FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bfu OCA], [https://pdbe.org/2bfu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bfu RCSB], [https://www.ebi.ac.uk/pdbsum/2bfu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bfu ProSAT]</span></td></tr>
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{{STRUCTURE_2bfu| PDB=2bfu | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/POL2_CPMVS POL2_CPMVS] Movement protein: transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Acts by forming a tubular structure at the host plasmodesmata, enlarging it enough to allow free passage of virion capsids. Binds to GTP and to single-stranded RNA and single-stranded DNA in a non-sequence-specific manner.<ref>PMID:10049828</ref> <ref>PMID:15483261</ref> <ref>PMID:15165817</ref> <ref>PMID:14722313</ref> The cleavable C-terminus of small coat protein seems to be involved in the packaging of the virion RNAs. Also seems to act as suppressor of post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs.<ref>PMID:10049828</ref> <ref>PMID:15483261</ref> <ref>PMID:15165817</ref> <ref>PMID:14722313</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bf/2bfu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bfu ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Chemical and genetic modifications on the surface of viral protein cages confer unique properties to the virus particles with potential nano and biotechnological applications. The enclosed space in the interior of the virus particles further increases its versatility as a nanomaterial. In this paper, we report a simple method to generate a high yield of stable cowpea mosaic virus (CPMV) empty capsids from their native nucleoprotein counterparts by removing the encapsidated viral genome without compromising the integrity of the protein coat. Biochemical and structural comparison of artificially generated empty particles did not reveal any distinguishable differences from CPMV particles containing viral RNA. Preliminary results on the use of artificially produced empty CPMV capsids as a carrier capsule are described.
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===X-RAY STRUCTURE OF CPMV TOP COMPONENT===
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Generation and structural analysis of reactive empty particles derived from an icosahedral virus.,Ochoa WF, Chatterji A, Lin T, Johnson JE Chem Biol. 2006 Jul;13(7):771-8. PMID:16873025<ref>PMID:16873025</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2bfu" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_16873025}}, adds the Publication Abstract to the page
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*[[Cowpea Chlorotic Mottle Virus|Cowpea Chlorotic Mottle Virus]]
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(as it appears on PubMed at http://www.pubmed.gov), where 16873025 is the PubMed ID number.
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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== References ==
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{{ABSTRACT_PUBMED_16873025}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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2BFU is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Cowpea_mosaic_virus Cowpea mosaic virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BFU OCA].
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==Reference==
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<ref group="xtra">PMID:16873025</ref><references group="xtra"/>
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[[Category: Cowpea mosaic virus]]
[[Category: Cowpea mosaic virus]]
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[[Category: Chatterji, A.]]
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[[Category: Large Structures]]
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[[Category: Johnson, J E.]]
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[[Category: Chatterji A]]
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[[Category: Lin, T.]]
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[[Category: Johnson JE]]
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[[Category: Ochoa, W F.]]
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[[Category: Lin T]]
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[[Category: Comovirus]]
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[[Category: Ochoa WF]]
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[[Category: Cowpea mosaic virus cpmv]]
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[[Category: Empty particle]]
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[[Category: Icosahedral virus]]
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[[Category: Nanotechnology]]
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[[Category: Top component]]
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[[Category: Viral coat protein]]
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[[Category: Virus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 11 22:43:02 2009''
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Current revision

X-ray structure of CPMV top component

PDB ID 2bfu

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