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3fhk

From Proteopedia

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{{Seed}}
 
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[[Image:3fhk.png|left|200px]]
 
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==Crystal structure of APC1446, B.subtilis YphP disulfide isomerase==
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The line below this paragraph, containing "STRUCTURE_3fhk", creates the "Structure Box" on the page.
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<StructureSection load='3fhk' size='340' side='right'caption='[[3fhk]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3fhk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FHK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FHK FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3fhk| PDB=3fhk | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fhk OCA], [https://pdbe.org/3fhk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fhk RCSB], [https://www.ebi.ac.uk/pdbsum/3fhk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fhk ProSAT], [https://www.topsan.org/Proteins/ISFI/3fhk TOPSAN]</span></td></tr>
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</table>
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===Crystal structure of APC1446, B.subtilis YphP disulfide isomerase===
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== Function ==
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[https://www.uniprot.org/uniprot/BRXA_BACSU BRXA_BACSU] S-bacillithiolation is the formation of mixed disulfide bonds between protein thiols and the general thiol reductant bacillithiol (BSH) under oxidative stress. BSH is an equivalent of glutathione (GSH) in Firmicutes. This protein is a dithiol bacilliredoxin, which debacillithiolates (removes BSH) the S-bacillithiolated OhrR (OhrR-SSB) in vitro and in vivo NaOCl-generated S-bacillithiolated MetE (MetE-SSB). Involved in maintaining redox homeostasis in response to disulfide stress conditions (PubMed:24313874). Has a redox potential of -130 mV. Displays weak protein disulfide isomerase activity in vitro (PubMed:19653655).<ref>PMID:19653655</ref> <ref>PMID:24313874</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_19653655}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 19653655 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fh/3fhk_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_19653655}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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3FHK is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FHK OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fhk ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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<ref group="xtra">PMID:19653655</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
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[[Category: Boczek, T.]]
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[[Category: Large Structures]]
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[[Category: Cooper, D R.]]
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[[Category: Boczek T]]
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[[Category: Derewenda, U.]]
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[[Category: Cooper DR]]
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[[Category: Derewenda, Z S.]]
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[[Category: Derewenda U]]
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[[Category: Hung, L.]]
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[[Category: Derewenda ZS]]
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[[Category: ISFI, Integrated Center for Structure and Function Innovation.]]
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[[Category: Hung L]]
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[[Category: Yu, M.]]
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[[Category: Yu M]]
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[[Category: Cxc motif]]
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[[Category: Disulfide isomerase]]
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[[Category: Integrated center for structure and function innovation]]
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[[Category: Isfi]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-2]]
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[[Category: Ser]]
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[[Category: Structural genomic]]
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[[Category: Surface entropy reduction]]
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[[Category: Thioredoxin superfamily]]
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[[Category: Unknown function]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 11 22:52:50 2009''
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Current revision

Crystal structure of APC1446, B.subtilis YphP disulfide isomerase

PDB ID 3fhk

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