1dlp

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(New page: 200px<br /><applet load="1dlp" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dlp, resolution 3.3&Aring;" /> '''STRUCTURAL CHARACTERI...)
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[[Image:1dlp.gif|left|200px]]<br /><applet load="1dlp" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1dlp, resolution 3.3&Aring;" />
 
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'''STRUCTURAL CHARACTERIZATION OF THE NATIVE FETUIN-BINDING PROTEIN SCILLA CAMPANULATA AGGLUTININ (SCAFET): A NOVEL TWO-DOMAIN LECTIN'''<br />
 
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==Overview==
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==STRUCTURAL CHARACTERIZATION OF THE NATIVE FETUIN-BINDING PROTEIN SCILLA CAMPANULATA AGGLUTININ (SCAFET): A NOVEL TWO-DOMAIN LECTIN==
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The three-dimensional structure of a 244-residue, multivalent, fetuin-binding lectin, SCAfet, isolated from bluebell (Scilla campanulata), bulbs, has been solved at 3.3 A resolution by molecular replacement using, the coordinates of the 119-residue, mannose-binding lectin, SCAman, also, from bluebell bulbs. Unlike most monocot mannose-binding lectins, such as, Galanthus nivalis agglutinin from snowdrop bulbs, which fold into a single, domain, SCAfet contains two domains with approximately 55% sequence, identity, joined by a linker peptide. Both domains are made up of a, 12-stranded beta-prism II fold, with three putative carbohydrate-binding, sites, one on each subdomain. SCAfet binds to the complex saccharides of, various animal glycoproteins but not to simple sugars.
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<StructureSection load='1dlp' size='340' side='right'caption='[[1dlp]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1dlp]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Hyacinthoides_hispanica Hyacinthoides hispanica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DLP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DLP FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dlp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dlp OCA], [https://pdbe.org/1dlp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dlp RCSB], [https://www.ebi.ac.uk/pdbsum/1dlp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dlp ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9ZP48_HYAHI Q9ZP48_HYAHI]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dl/1dlp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dlp ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The three-dimensional structure of a 244-residue, multivalent, fetuin-binding lectin, SCAfet, isolated from bluebell (Scilla campanulata) bulbs, has been solved at 3.3 A resolution by molecular replacement using the coordinates of the 119-residue, mannose-binding lectin, SCAman, also from bluebell bulbs. Unlike most monocot mannose-binding lectins, such as Galanthus nivalis agglutinin from snowdrop bulbs, which fold into a single domain, SCAfet contains two domains with approximately 55% sequence identity, joined by a linker peptide. Both domains are made up of a 12-stranded beta-prism II fold, with three putative carbohydrate-binding sites, one on each subdomain. SCAfet binds to the complex saccharides of various animal glycoproteins but not to simple sugars.
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==About this Structure==
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Structural characterisation of the native fetuin-binding protein Scilla campanulata agglutinin: a novel two-domain lectin.,Wright LM, Reynolds CD, Rizkallah PJ, Allen AK, Van Damme EJ, Donovan MJ, Peumans WJ FEBS Lett. 2000 Feb 18;468(1):19-22. PMID:10683433<ref>PMID:10683433</ref>
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1DLP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Hyacinthoides_hispanica Hyacinthoides hispanica]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DLP OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Structural characterisation of the native fetuin-binding protein Scilla campanulata agglutinin: a novel two-domain lectin., Wright LM, Reynolds CD, Rizkallah PJ, Allen AK, Van Damme EJ, Donovan MJ, Peumans WJ, FEBS Lett. 2000 Feb 18;468(1):19-22. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10683433 10683433]
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</div>
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[[Category: Hyacinthoides hispanica]]
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<div class="pdbe-citations 1dlp" style="background-color:#fffaf0;"></div>
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[[Category: Single protein]]
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[[Category: Allen, A.K.]]
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[[Category: Donovan, M.J.]]
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[[Category: Peumans, W.J.]]
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[[Category: Reynolds, C.D.]]
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[[Category: Rizkallah, P.J.]]
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[[Category: VanDamme, E.J.M.]]
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[[Category: Wright, L.M.]]
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[[Category: beta prism ii fold]]
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[[Category: native]]
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[[Category: two-domain lectin]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 03:17:39 2007''
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==See Also==
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*[[Agglutinin 3D structures|Agglutinin 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Hyacinthoides hispanica]]
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[[Category: Large Structures]]
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[[Category: Allen AK]]
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[[Category: Donovan MJ]]
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[[Category: Peumans WJ]]
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[[Category: Reynolds CD]]
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[[Category: Rizkallah PJ]]
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[[Category: VanDamme EJM]]
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[[Category: Wright LM]]

Current revision

STRUCTURAL CHARACTERIZATION OF THE NATIVE FETUIN-BINDING PROTEIN SCILLA CAMPANULATA AGGLUTININ (SCAFET): A NOVEL TWO-DOMAIN LECTIN

PDB ID 1dlp

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