3ere

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{{Seed}}
 
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[[Image:3ere.png|left|200px]]
 
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==Crystal structure of the arginine repressor protein from Mycobacterium tuberculosis in complex with the DNA operator==
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The line below this paragraph, containing "STRUCTURE_3ere", creates the "Structure Box" on the page.
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<StructureSection load='3ere' size='340' side='right'caption='[[3ere]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ere]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ERE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ERE FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3ere| PDB=3ere | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ere FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ere OCA], [https://pdbe.org/3ere PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ere RCSB], [https://www.ebi.ac.uk/pdbsum/3ere PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ere ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ARGR_MYCTU ARGR_MYCTU] Regulates arginine biosynthesis genes (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/er/3ere_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ere ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The arginine repressor (ArgR) from Mycobacterium tuberculosis (Mtb) is a gene product encoded by the open reading frame Rv1657. It regulates the L-arginine concentration in cells by interacting with ARG boxes in the promoter regions of the arginine biosynthesis and catabolism operons. Here we present a 2.5-A structure of MtbArgR in complex with a 16-bp DNA operator in the absence of arginine. A biological trimer of the protein-DNA complex is formed via the crystallographic 3-fold symmetry axis. The N-terminal domain of MtbArgR has a winged helix-turn-helix motif that binds to the major groove of the DNA. This structure shows that, in the absence of arginine, the ArgR trimer can bind three ARG box half-sites. It also reveals the structure of the whole MtbArgR molecule itself containing both N-terminal and C-terminal domains.
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===Crystal structure of the arginine repressor protein from Mycobacterium tuberculosis in complex with the DNA operator===
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Crystal structure of the arginine repressor protein in complex with the DNA operator from Mycobacterium tuberculosis.,Cherney LT, Cherney MM, Garen CR, Lu GJ, James MN J Mol Biol. 2008 Dec 31;384(5):1330-40. Epub 2008 Oct 15. PMID:18952097<ref>PMID:18952097</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3ere" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_18952097}}, adds the Publication Abstract to the page
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*[[Arginine repressor 3D structures|Arginine repressor 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 18952097 is the PubMed ID number.
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*[[Tomato aspermy virus protein 2b Suppression of RNA Silencing|Tomato aspermy virus protein 2b Suppression of RNA Silencing]]
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== References ==
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{{ABSTRACT_PUBMED_18952097}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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3ERE is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ERE OCA].
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[[Category: Large Structures]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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==Reference==
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[[Category: Cherney LT]]
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<ref group="xtra">PMID:18952097</ref><references group="xtra"/>
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[[Category: Cherney MM]]
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[[Category: Mycobacterium tuberculosis h37rv]]
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[[Category: Garen CR]]
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[[Category: Cherney, L T.]]
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[[Category: James MN]]
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[[Category: Cherney, M M.]]
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[[Category: Lu GJ]]
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[[Category: Garen, C R.]]
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[[Category: James, M N.]]
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[[Category: Lu, G J.]]
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[[Category: TBSGC, TB Structural Genomics Consortium.]]
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[[Category: Amino-acid biosynthesis]]
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[[Category: Arginine biosynthesis]]
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[[Category: Arginine repressor protein]]
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[[Category: Argr-operator complex]]
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[[Category: Cytoplasm]]
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[[Category: Dna binding]]
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[[Category: Dna binding protein/dna complex]]
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[[Category: Dna-binding]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Structural genomic]]
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[[Category: Tb structural genomic]]
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[[Category: Tb structural genomics consortium]]
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[[Category: Tbsgc]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: X-ray crystallography]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 18 18:19:20 2009''
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Current revision

Crystal structure of the arginine repressor protein from Mycobacterium tuberculosis in complex with the DNA operator

PDB ID 3ere

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OCA

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