1y26

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(New page: 200px<br /><applet load="1y26" size="450" color="white" frame="true" align="right" spinBox="true" caption="1y26, resolution 2.10&Aring;" /> '''A-riboswitch-adenine...)
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[[Image:1y26.gif|left|200px]]<br /><applet load="1y26" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1y26, resolution 2.10&Aring;" />
 
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'''A-riboswitch-adenine complex'''<br />
 
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==Overview==
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==A-riboswitch-adenine complex==
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Metabolite-sensing mRNAs, or "riboswitches," specifically interact with, small ligands and direct expression of the genes involved in their, metabolism. Riboswitches contain sensing "aptamer" modules, capable of, ligand-induced structural changes, and downstream regions, harboring, expression-controlling elements. We report the crystal structures of the, add A-riboswitch and xpt G-riboswitch aptamer modules that distinguish, between bound adenine and guanine with exquisite specificity and modulate, expression of two different sets of genes. The riboswitches form tuning, fork-like architectures, in which the prongs are held in parallel through, hairpin loop interactions, and the internal bubble zippers up to form the, purine binding pocket. The bound purines are held by hydrogen bonding, interactions involving conserved nucleotides along their entire periphery., Recognition specificity is associated with Watson-Crick pairing of the, encapsulated adenine and guanine ligands with uridine and cytosine, respectively.
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<StructureSection load='1y26' size='340' side='right'caption='[[1y26]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1y26]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_vulnificus Vibrio vulnificus]. The October 2010 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Riboswitches'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2010_10 10.2210/rcsb_pdb/mom_2010_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y26 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y26 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADE:ADENINE'>ADE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y26 OCA], [https://pdbe.org/1y26 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y26 RCSB], [https://www.ebi.ac.uk/pdbsum/1y26 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y26 ProSAT]</span></td></tr>
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</table>
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==About this Structure==
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==See Also==
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1Y26 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Vibrio_vulnificus Vibrio vulnificus] with MG and ADE as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1Y26 OCA].
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*[[Riboswitch|Riboswitch]]
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*[[Riboswitch 3D structures|Riboswitch 3D structures]]
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==Reference==
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__TOC__
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Structural basis for discriminative regulation of gene expression by adenine- and guanine-sensing mRNAs., Serganov A, Yuan YR, Pikovskaya O, Polonskaia A, Malinina L, Phan AT, Hobartner C, Micura R, Breaker RR, Patel DJ, Chem Biol. 2004 Dec;11(12):1729-41. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15610857 15610857]
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</StructureSection>
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Riboswitches]]
[[Category: Vibrio vulnificus]]
[[Category: Vibrio vulnificus]]
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[[Category: Patel, D.J.]]
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[[Category: Patel DJ]]
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[[Category: Serganov, A.]]
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[[Category: Serganov A]]
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[[Category: Yuan, Y.R.]]
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[[Category: Yuan YR]]
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[[Category: ADE]]
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[[Category: MG]]
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[[Category: a-riboswitch adenine recognition]]
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[[Category: crystal structure]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 03:22:46 2007''
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A-riboswitch-adenine complex

PDB ID 1y26

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