2ajq

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{{Seed}}
 
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[[Image:2ajq.png|left|200px]]
 
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==Structure of replicative DNA polymerase provides insigts into the mechanisms for processivity, frameshifting and editing==
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The line below this paragraph, containing "STRUCTURE_2ajq", creates the "Structure Box" on the page.
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<StructureSection load='2ajq' size='340' side='right'caption='[[2ajq]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ajq]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Escherichia_phage_T7 Escherichia phage T7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AJQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AJQ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2DT:3-DEOXYTHYMIDINE-5-MONOPHOSPHATE'>2DT</scene></td></tr>
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{{STRUCTURE_2ajq| PDB=2ajq | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ajq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ajq OCA], [https://pdbe.org/2ajq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ajq RCSB], [https://www.ebi.ac.uk/pdbsum/2ajq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ajq ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DPOL_BPT7 DPOL_BPT7] Replicates viral genomic DNA. Non-processive DNA polymerase that achieves processivity by binding to host thioredoxin (TrxA). This interaction increases the rate of dNTP incorporation to yield a processivity of approximately 800 nucleotides (nt) per binding event. Interacts with DNA helicase gp4 to coordinate nucleotide polymerization with unwinding of the DNA. The leading strand is synthesized continuously while synthesis of the lagging strand requires the synthesis of oligoribonucleotides by the primase domain of gp4.<ref>PMID:9218486</ref> <ref>PMID:21606333</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aj/2ajq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ajq ConSurf].
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<div style="clear:both"></div>
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===Strucuture of replicative DNA polymerase provides insigts into the mechanisms for processivity, frameshifting and editing===
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==See Also==
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*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
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*[[Thioredoxin 3D structures|Thioredoxin 3D structures]]
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==About this Structure==
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== References ==
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2AJQ is a 8 chains structure of sequences from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t7 Enterobacteria phage t7] and [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AJQ OCA].
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<references/>
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[[Category: DNA-directed DNA polymerase]]
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__TOC__
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[[Category: Enterobacteria phage t7]]
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Brieba, L.]]
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[[Category: Escherichia phage T7]]
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[[Category: Ellenberger, T.]]
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[[Category: Large Structures]]
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[[Category: Polymerase t7]]
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[[Category: Brieba L]]
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[[Category: Ternary complex]]
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[[Category: Ellenberger T]]
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[[Category: Transcription/dna complex]]
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[[Category: Transferase]]
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[[Category: X-ray crystallography]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 18 20:18:38 2009''
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Current revision

Structure of replicative DNA polymerase provides insigts into the mechanisms for processivity, frameshifting and editing

PDB ID 2ajq

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