2gib

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{{Seed}}
 
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[[Image:2gib.png|left|200px]]
 
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==Crystal structure of the SARS coronavirus nucleocapsid protein dimerization domain==
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The line below this paragraph, containing "STRUCTURE_2gib", creates the "Structure Box" on the page.
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<StructureSection load='2gib' size='340' side='right'caption='[[2gib]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2gib]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome-related_coronavirus Severe acute respiratory syndrome-related coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GIB FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_2gib| PDB=2gib | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gib OCA], [https://pdbe.org/2gib PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gib RCSB], [https://www.ebi.ac.uk/pdbsum/2gib PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gib ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NCAP_SARS NCAP_SARS] Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication (PubMed:17210170). May modulate transforming growth factor-beta signaling by binding host SMAD3 (PubMed:18055455).[HAMAP-Rule:MF_04096]<ref>PMID:17210170</ref> <ref>PMID:18055455</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gi/2gib_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gib ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of the SARS coronavirus nucleocapsid protein dimerization domain===
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==See Also==
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*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 16627473 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_16627473}}
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[[Category: Severe acute respiratory syndrome-related coronavirus]]
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[[Category: Chen J]]
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==About this Structure==
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[[Category: Oldham ML]]
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2GIB is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIB OCA].
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[[Category: Yu IM]]
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[[Category: Zhang J]]
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==Reference==
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<ref group="xtra">PMID:16627473</ref><references group="xtra"/>
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[[Category: Sars coronavirus]]
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[[Category: Chen, J.]]
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[[Category: Oldham, M L.]]
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[[Category: Yu, I M.]]
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[[Category: Zhang, J.]]
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[[Category: Dimer]]
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[[Category: Nucleocapsid]]
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[[Category: Sar]]
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[[Category: Viral protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 18 20:30:50 2009''
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Current revision

Crystal structure of the SARS coronavirus nucleocapsid protein dimerization domain

PDB ID 2gib

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