1u9s

[[Image:1u9s.gif|left|200px]]<br /><applet load="1u9s" size="450" color="white" frame="true" align="right" spinBox="true"

caption="1u9s, resolution 2.90&Aring;" />

'''Crystal structure of the specificity domain of Ribonuclease P of the A-type'''<br />

==Overview==

Large RNA molecules, such as ribozymes, fold with well-defined tertiary, structures that are important for their activity. There are many instances, of ribozymes with identical function but differences in their secondary, structures, suggesting alternative tertiary folds. Here, we report a, crystal structure of the 161-nucleotide specificity domain of an A-type, ribonuclease P that differs in secondary and tertiary structure from the, specificity domain of a B-type molecule. Despite the differences, the, cores of the domains have similar three-dimensional structure. Remarkably, the similar geometry of the cores is stabilized by a different set of, interactions involving distinct auxiliary elements.

==About this Structure==

1U9S is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with BA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1U9S OCA].

 

Basis for structural diversity in homologous RNAs., Krasilnikov AS, Xiao Y, Pan T, Mondragon A, Science. 2004 Oct 1;306(5693):104-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15459389 15459389]

[[Category: Single protein]]

[[Category: Krasilnikov, A.S.]]

[[Category: Mondragon, A.]]

[[Category: Pan, T.]]

[[Category: Xiao, Y.]]