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1q5f

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(New page: 200px<br /><applet load="1q5f" size="450" color="white" frame="true" align="right" spinBox="true" caption="1q5f" /> '''NMR Structure of Type IVb pilin (PilS) from ...)
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[[Image:1q5f.jpg|left|200px]]<br /><applet load="1q5f" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1q5f" />
 
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'''NMR Structure of Type IVb pilin (PilS) from Salmonella typhi'''<br />
 
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==Overview==
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==NMR Structure of Type IVb pilin (PilS) from Salmonella typhi==
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The structure of the N-terminal-truncated Type IVb structural pilin, (t-PilS) from Salmonella typhi was determined by NMR. Although, topologically similar to the recently determined x-ray structure of pilin, from Vibrio cholerae toxin-coregulated pilus, the only Type IVb pilin with, known structure, t-PilS contains many distinct structural features. The, protein contains an extra pair of beta-strands in the N-terminal alphabeta, loop that align with the major beta-strands to form a continuous, 7-stranded antiparallel beta-sheet. The C-terminal disulfide-bonded region, of t-PilS is only half the length of that of toxin-coregulated pilus, pilin. A model of S. typhi pilus has been proposed and mutagenesis studies, suggested that residues on both the alphabeta loop and the C-terminal, disulfide-bonded region of PilS might be involved in binding specificity, of the pilus. This model structure reveals an exposed surface between, adjacent subunits of PilS that could be a potential binding site for the, cystic fibrosis transmembrane conductance regulator.
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<StructureSection load='1q5f' size='340' side='right'caption='[[1q5f]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1q5f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhi Salmonella enterica subsp. enterica serovar Typhi]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q5F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q5F FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q5f OCA], [https://pdbe.org/1q5f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q5f RCSB], [https://www.ebi.ac.uk/pdbsum/1q5f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q5f ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9ZIU9_SALTI Q9ZIU9_SALTI]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q5/1q5f_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q5f ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1Q5F is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Salmonella_typhi Salmonella typhi]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1Q5F OCA].
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*[[Pilin 3D structures|Pilin 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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NMR structure of a type IVb pilin from Salmonella typhi and its assembly into pilus., Xu XF, Tan YW, Lam L, Hackett J, Zhang M, Mok YK, J Biol Chem. 2004 Jul 23;279(30):31599-605. Epub 2004 May 24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15159389 15159389]
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[[Category: Large Structures]]
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[[Category: Salmonella typhi]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhi]]
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[[Category: Single protein]]
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[[Category: Hackett J]]
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[[Category: Hackett, J.]]
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[[Category: Mok YK]]
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[[Category: Mok, Y.K.]]
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[[Category: Tan YW]]
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[[Category: Tan, Y.W.]]
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[[Category: Xu XF]]
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[[Category: Xu, X.F.]]
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[[Category: Zhang M]]
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[[Category: Zhang, M.]]
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[[Category: alpha-beta roll]]
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[[Category: monomer]]
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[[Category: type ivb pilin]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 03:36:27 2007''
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Current revision

NMR Structure of Type IVb pilin (PilS) from Salmonella typhi

PDB ID 1q5f

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