3a8q

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[[Image:3a8q.jpg|left|200px]]
 
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==Low-resolution crystal structure of the Tiam2 PHCCEx domain==
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The line below this paragraph, containing "STRUCTURE_3a8q", creates the "Structure Box" on the page.
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<StructureSection load='3a8q' size='340' side='right'caption='[[3a8q]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3a8q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A8Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A8Q FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a8q OCA], [https://pdbe.org/3a8q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a8q RCSB], [https://www.ebi.ac.uk/pdbsum/3a8q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a8q ProSAT]</span></td></tr>
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{{STRUCTURE_3a8q| PDB=3a8q | SCENE= }}
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</table>
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== Function ==
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===Low-resolution crystal structure of the Tiam2 PHCCEx domain===
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[https://www.uniprot.org/uniprot/TIAM2_MOUSE TIAM2_MOUSE] Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates specifically RAC1, but not CDC42 and RHOA. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane.<ref>PMID:10364228</ref> <ref>PMID:11707441</ref> <ref>PMID:12912917</ref> <ref>PMID:14550769</ref> <ref>PMID:17320046</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19893486 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a8/3a8q_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_19893486}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3a8q ConSurf].
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3A8Q is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A8Q OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:19893486</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Hakoshima, T.]]
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[[Category: Hakoshima T]]
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[[Category: Higuchi, Y.]]
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[[Category: Higuchi Y]]
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[[Category: Itoh, N.]]
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[[Category: Itoh N]]
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[[Category: Kaibuchi, K.]]
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[[Category: Kaibuchi K]]
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[[Category: Kitano, K.]]
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[[Category: Kitano K]]
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[[Category: Mori, T.]]
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[[Category: Mori T]]
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[[Category: Terawaki, S.]]
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[[Category: Terawaki S]]
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[[Category: Watanabe, T.]]
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[[Category: Watanabe T]]
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[[Category: Zhai, Y.]]
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[[Category: Zhai Y]]
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[[Category: Alternative splicing]]
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[[Category: Cell projection]]
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[[Category: Coiled coil]]
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[[Category: Cytoplasm]]
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[[Category: Guanine nucleotide exchange factor]]
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[[Category: Guanine-nucleotide releasing factor]]
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[[Category: Lipoprotein]]
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[[Category: Myristate]]
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[[Category: Phosphoprotein]]
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[[Category: Signaling protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 25 09:42:57 2009''
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Current revision

Low-resolution crystal structure of the Tiam2 PHCCEx domain

PDB ID 3a8q

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OCA

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