2kpw

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{{Seed}}
 
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[[Image:2kpw.png|left|200px]]
 
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==NMR solution structure of Lamin-B1 protein from Homo sapiens: Northeast Structural Genomics Consortium MEGA target, HR5546A (439-549)==
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The line below this paragraph, containing "STRUCTURE_2kpw", creates the "Structure Box" on the page.
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<StructureSection load='2kpw' size='340' side='right'caption='[[2kpw]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2kpw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KPW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KPW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kpw OCA], [https://pdbe.org/2kpw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kpw RCSB], [https://www.ebi.ac.uk/pdbsum/2kpw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kpw ProSAT]</span></td></tr>
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{{STRUCTURE_2kpw| PDB=2kpw | SCENE= }}
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</table>
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== Disease ==
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===NMR solution structure of Lamin-B1 protein from Homo sapiens: Northeast Structural Genomics Consortium MEGA target, HR5546A (439-549)===
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[https://www.uniprot.org/uniprot/LMNB1_HUMAN LMNB1_HUMAN] Defects in LMNB1 are the cause of leukodystrophy demyelinating autosomal dominant adult-onset (ADLD) [MIM:[https://omim.org/entry/169500 169500]. ADLD is a slowly progressive and fatal demyelinating leukodystrophy, presenting in the fourth or fifth decade of life. Clinically characterized by early autonomic abnormalities, pyramidal and cerebellar dysfunction, and symmetric demyelination of the CNS. It differs from multiple sclerosis and other demyelinating disorders in that neuropathology shows preservation of oligodendroglia in the presence of subtotal demyelination and lack of astrogliosis.<ref>PMID:16951681</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/LMNB1_HUMAN LMNB1_HUMAN] Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
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==About this Structure==
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== Evolutionary Conservation ==
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2KPW is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KPW OCA].
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kp/2kpw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kpw ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Acton, T.]]
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[[Category: Large Structures]]
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[[Category: Belote, R.]]
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[[Category: Acton T]]
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[[Category: Ciccosanti, C L.]]
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[[Category: Belote R]]
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[[Category: Everett, J.]]
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[[Category: Ciccosanti CL]]
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[[Category: Hamilton, K.]]
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[[Category: Everett J]]
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[[Category: Huang, Y.]]
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[[Category: Hamilton K]]
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[[Category: Montelione, G T.]]
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[[Category: Huang Y]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Montelione GT]]
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[[Category: Swapna, G V.T.]]
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[[Category: Swapna GVT]]
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[[Category: Xiao, R.]]
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[[Category: Xiao R]]
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[[Category: Acetylation]]
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[[Category: Chromosomal rearrangement]]
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[[Category: Coiled coil]]
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[[Category: Gft]]
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[[Category: Hr5546a]]
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[[Category: Intermediate filament]]
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[[Category: Lamin-b1]]
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[[Category: Leukodystrophy]]
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[[Category: Lipoprotein]]
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[[Category: Membrane]]
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[[Category: Nesg]]
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[[Category: Northeast structural genomics consortium]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Prenylation]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-2]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 25 10:26:55 2009''
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Current revision

NMR solution structure of Lamin-B1 protein from Homo sapiens: Northeast Structural Genomics Consortium MEGA target, HR5546A (439-549)

PDB ID 2kpw

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